A novel therapeutic strategy for acute decompensated heart failure with vasodilators

作者全名："Pana, Yu; Yang, Juan; Feng, Zhu Qing; Yuan, Yan; Tang, Xue Yin; Dong, Jiang Chuan"

作者地址："[Pana, Yu; Feng, Zhu Qing; Yuan, Yan; Tang, Xue Yin; Dong, Jiang Chuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, Chongqing 400010, Peoples R China; [Yang, Juan] Chongqing Med Univ, Affiliated Hosp 1, Dept Combinat Chinese & Western Med, Chongqing 400016, Peoples R China; [Dong, Jiang Chuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Dong, JC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：MEDICAL HYPOTHESES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001182621900001

JCR分区：Q3

影响因子：2.1

年份：2024

卷号：184

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Heart failure; Vasodilators; Diuretics; Congestion; Therapeutics

摘要："Acute decompensated heart failure (ADHF) is a condition of substantial public health significance, marked by elevated morbidity and mortality rates. Despite advancements in the management of chronic heart failure, effective interventions for ADHF remain elusive. The cardinal manifestations of ADHF primarily stem from congestion, underscoring the pivotal role of vasodilators in a comprehensive therapeutic approach for individuals afflicted with this condition. In recent years, diuretics have been widely regarded as the primary treatment for ADHF, while vasodilators have often been neglected. Despite diuretics have demonstrated efficacy, their therapeutic strategies have not yielded the anticipated level of success. Consequently, we hypothesize a novel therapeutic strategy for ADHF, wherein vasodilators assume a central role, with a heightened emphasis on the correct application of the medications and a diminished reliance on diuretics, all with the intention of optimizing the healing effect provided to ADHF patients in enhancing their prognosis and quality of life."

基金机构：Chongqing Medical University [W0070]; Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0125]

基金资助正文："This work was supported by the 2021 Future Medical Innovation Team Support Program of Chongqing Medical University (Project No. W0070) and Chongqing Natural Science Foundation (Project No. CSTB2022NSCQ-MSX0125). Fig. 1 was drawn by Figdraw, and the authors would like to thank the staff at Figdraw."