Epilepsy and childhood psychiatric disorders: a two-sample bidirectional Mendelian randomization study

作者全名："Wu, Yuxin; Zhang, Zaiyu; Dong, Xinyu; Liang, Ping; Li, Lusheng; Zhai, Xuan; Zou, Bin"

作者地址："[Wu, Yuxin; Zhang, Zaiyu; Dong, Xinyu; Liang, Ping; Li, Lusheng; Zhai, Xuan; Zou, Bin] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders,Dept Neur, Minist Educ,Dept Dermatol,Key Lab Child Dev & Diso, 136 Zhongshan Second Rd, Chongqing 400016, Peoples R China; [Wu, Yuxin; Zhang, Zaiyu; Dong, Xinyu; Liang, Ping; Li, Lusheng; Zhai, Xuan; Zou, Bin] Chongqing Key Lab Translat Med Res Cognit Dev & Le, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing, Peoples R China"

通信作者："Zou, B (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders,Dept Neur, Minist Educ,Dept Dermatol,Key Lab Child Dev & Diso, 136 Zhongshan Second Rd, Chongqing 400016, Peoples R China.; Zou, B (通讯作者)，Chongqing Key Lab Translat Med Res Cognit Dev & Le, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing, Peoples R China."

来源：NEUROLOGICAL SCIENCES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001184124200001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Epilepsy; Mendelian randomization; Attention deficit hyperactivity disorder; Autism spectrum disorder; Tourette syndrome

摘要："BackgroundObservational studies have indicated that psychiatric disorders are the most common comorbidities in pediatric epilepsy. However, the existence and direction of a causal relationship between the two remains controversial. This study aims to investigate the association between common childhood psychiatric disorders and epilepsy using a two-sample, bidirectional Mendelian randomization (MR) approach.MethodsGenetic instruments were obtained from the most recent and largest genome-wide association studies (GWAS), including datasets for epilepsy (N_case = 29,994, N_control = 52,538), attention deficit hyperactivity disorder (ADHD) (N_case = 38,691, N_control = 186,843), autism spectrum disorder (ASD) (N_case = 18,381, N_control = 27,969), and Tourette syndrome (TS) (N_case = 4,819, N_control = 9488). MR analyses were conducted using the inverse variance weighted (IVW) method, weighted median method, and MR-Egger regression.ResultsNo reliable evidence was found to suggest a causal effect of ADHD, ASD, or TS on epilepsy, nor was there any reliable evidence indicating that epilepsy increases the risk of these three psychiatric disorders. These findings remained consistent across various sensitivity analyses.ConclusionAlthough observational studies have highlighted a high comorbidity rate between pediatric epilepsy and psychiatric disorders like ADHD and ASD, the MR analysis did not confirm a causal relationship between them. This suggests that previous studies might have been influenced by confounding biases or other biases, potentially overestimating the true relationship. A deeper understanding of the mechanisms underlying these comorbidities is crucial for refining the treatment of pediatric epilepsy."

基金机构：National Natural Science Foundation of China

基金资助正文：No Statement Available