Causal relationship between iron status and preeclampsia-eclampsia: a Mendelian randomization analysis

作者全名："Yang, Xiaofeng; Wei, Jiachun; Sun, Lu; Zhong, Qimei; Zhai, Xiaoxuan; Chen, Ya; Luo, Shujuan; Tang, Chunyan; Wang, Lan"

作者地址："[Yang, Xiaofeng; Zhong, Qimei; Zhai, Xiaoxuan; Chen, Ya; Luo, Shujuan; Tang, Chunyan; Wang, Lan] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Yang, Xiaofeng; Zhong, Qimei; Zhai, Xiaoxuan; Chen, Ya; Luo, Shujuan; Tang, Chunyan; Wang, Lan] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Wei, Jiachun; Sun, Lu] Jinan Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Peoples R China; [Wang, Lan] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 401147, Peoples R China"

通信作者："Wang, L (通讯作者)，Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, 120 Longshan Rd, Chongqing 401147, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL HYPERTENSION

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001184283800001

JCR分区：Q3

影响因子：1.5

年份：2024

卷号：46

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Mendelian randomization; iron status; preeclampsia; causal relationship; genetic variants

摘要："Background Preeclampsia/eclampsia is a severe pregnancy-related disorder associated with hypertension and organ damage. While observational studies have suggested a link between maternal iron status and preeclampsia/eclampsia, the causal relationship remains unclear. The aim of this study was to investigate the genetic causality between iron status and preeclampsia/eclampsia using large-scale genome-wide association study (GWAS) summary data and Mendelian randomization (MR) analysis. Methods Summary data for the GWAS on preeclampsia/eclampsia and genetic markers related to iron status were obtained from the FinnGen Consortium and the IEU genetic databases. The ""TwoSampleMR"" software package in R was employed to test the genetic causality between these markers and preeclampsia/eclampsia. The inverse variance weighted (IVW) method was primarily used for MR analysis. Heterogeneity, horizontal pleiotropy, and potential outliers were evaluated for the MR analysis results. Results The random-effects IVW results showed that ferritin (OR = 1.11, 95% CI: .89-1.38, p = .341), serum iron (OR = .90, 95% CI: .75-1.09, p = .275), TIBC (OR = .98, 95% CI: .89-1.07, p = .613), and TSAT (OR = .94, 95% CI: .83-1.07, p = .354) have no genetic causal relationship with preeclampsia/eclampsia. There was no evidence of heterogeneity, horizontal pleiotropy, or possible outliers in our MR analysis (p > .05). Conclusions Our study did not detect a genetic causal relationship between iron status and preeclampsia/eclampsia. Nonetheless, this does not rule out a relationship between the two at other mechanistic levels."

基金机构：China Postdoctoral Science Foundation [2023M740431]

基金资助正文：This study was supported by the China Postdoctoral Science Foundation (No: 2023M740431).