Targeting inhibition of TCTP could inhibit proliferation and induce apoptosis in AML cells

作者全名："Xia, Di; Xu, Gui-Ping; Zhang, Ying-Ting; Yan, Wei -Wei; Pan, Xiao-Rong; Tong, Jian-Hua"

作者地址："[Xia, Di; Zhang, Ying-Ting; Tong, Jian-Hua] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Cent Lab, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China; [Xu, Gui-Ping] Chongqing Med Univ, Affiliated Hosp 2, Transfus Dept, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [Yan, Wei -Wei] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Univ Chinese Acad Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; [Pan, Xiao-Rong] Shanghai Jiao Tong Univ, Rui Jin Hosp, Coll Hlth Sci & Technol, Fac Med Lab Sci,Sch Med, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China; [Pan, Xiao-Rong; Tong, Jian-Hua] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China"

通信作者："Pan, XR; Tong, JH (通讯作者)，Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China."

来源：CELLULAR SIGNALLING

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001184783300001

JCR分区：Q2

影响因子：4.4

年份：2024

卷号：117

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：TCTP; AML; Proliferation; Apoptosis

摘要："Translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein, which participates in many important physiological processes. Recently, the roles of TCTP in cell proliferation and apoptosis, especially its close relationship with various tumors, have attracted widespread attention. In this study, we found that the protein level of TCTP was significantly reduced in acute promyelocytic leukemia cell line NB4 transfected with retinoic acid -induced gene G (RIG -G). The RIG -G was found in our previous work as a key mediator of anti -proliferative activity in retinoid/interferon-related pathways. Here, we tried to further explore the function of TCTP in the development of acute myeloid leukemia (AML) from different levels. Our results showed that inhibiting TCTP expression could attenuate AML cells proliferation and induce apoptosis both in AML cell lines and in xenograft of NOD-SCID mice. In addition, either compared with patients in complete remission or nonleukemia patients, we detected that the expression of TCTP was generally high in the fresh bone marrow of AML patients, suggesting that there was a certain correlation between TCTP and AML disease progression. Taken together, our study revealed the role of TCTP in AML development, and provided a potential target for AML treatment."

基金机构：National Natural Science Foundation of China [81470317]; Leading Talent Program of Shanghai Municipal Human Resources and Social Security Bureau

基金资助正文："This work was supported in part by National Natural Science Foundation of China (81470317), Leading Talent Program of Shanghai Municipal Human Resources and Social Security Bureau."