Assessment of sleep disturbance in patients with Wilson's disease

作者全名："Wang, Zhengyang; You, Zhifei"

作者地址："[Wang, Zhengyang] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Wang, Zhengyang; You, Zhifei] Nanjing Med Univ, Jiangsu Taizhou Peoples Hosp, Dept Neurol, Taizhou Clin Med Sch, Taizhou 225300, Peoples R China"

通信作者："Wang, ZY (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Wang, ZY; You, ZF (通讯作者)，Nanjing Med Univ, Jiangsu Taizhou Peoples Hosp, Dept Neurol, Taizhou Clin Med Sch, Taizhou 225300, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001185050200002

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Wilson's disease; Sleep disturbance; Neurological variant; Mood; Depression

摘要："Background Wilson's disease (WD) is frequently manifested with anxiety, depression and sleep disturbance; this investigation aimed to elucidate these manifestations and identify the influencing factors of sleep disturbance. Methods Sleep disturbance, anxiety and depression were compared in 42 WD and 40 age- and gender-matched healthy individuals. 27 individuals indicated a neurological form of the disease (NV), and 15 had a non-neurological variant (NNV). Results This investigation revealed that the Parkinson's disease sleep scale (PDSS) score of WD individuals was lower, whereas their Epworth Sleepiness Scale (ESS), Pittsburgh sleep quality index (PSQI), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD) scores were higher than the healthy individuals (p < 0.05). Furthermore, the WD subjects had markedly increased prevalence of poor sleep quality, anxiety, and depression than healthy individuals (p < 0.05). Subgroup analysis showed that NV subjects had significantly higher scores on the UWDRS, PSQI, HAMA, and HAMD scales than those in the NV group, as well as higher rates of EDS, anxiety, and depression (p < 0.05). In patients with sleep disturbance, we identified UWDRS, neurological variant, and depression as associated factors. The linear regression model demonstrated depression as the dominant risk factor. Conclusions Depression is highly correlated with and is a determinant of sleep disturbance in WD patients."

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