Tumor Microenvironment Activatable Nanoprodrug System for In Situ Fluorescence Imaging and Therapy of Liver Cancer

作者全名："Xie, Can; Peng, Yongbo; Zhang, Zhen; Luo, Kun; Yang, Qiaomei; Tan, Libin; Zhou, Liyi"

作者地址："[Xie, Can; Luo, Kun; Yang, Qiaomei; Tan, Libin; Zhou, Liyi] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China; [Peng, Yongbo] Chongqing Med Univ, Coll Pharm, Key Lab Biochem & Mol Pharmacol, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Zhang, Zhen] Shandong Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Jinan 250355, Peoples R China"

通信作者："Zhou, LY (通讯作者)，Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China."

来源：ANALYTICAL CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:001185390500001

JCR分区：Q1

影响因子：6.7

年份：2024

卷号：96

期号：12

开始页：5006

结束页：5013

文献类型：Article

关键词：　

摘要："The development of new imaging and treatment nanoprodrug systems is highly demanded for diagnosis and therapy of liver cancer, a severe disease characterized by a high recurrence rate. Currently, available small molecule drugs are not possible for cancer diagnosis because of the fast diffusion of imaging agents and low efficacy in treatment due to poor water solubility and significant toxic side effects. In this study, we report the development of a tumor microenvironment activatable nanoprodrug system for the diagnosis and treatment of liver cancer. This nanoprodrug system can accumulate in the tumor site and be selectively activated by an excess of hydrogen peroxide (H2O2) in the tumor microenvironment, releasing near-infrared solid-state organic fluorescent probe (HPQCY-1) and phenylboronic acid-modified camptothecin (CPT) prodrug. Both HPQCY-1 and CPT prodrugs can be further activated in tumor sites for achieving more precise in situ near-infrared (NIR) fluorescence imaging and treatment while reducing the toxic effects of drugs on normal tissues. Additionally, the incorporation of hydrophilic multivalent chitosan as a carrier effectively improved the water solubility of the system. This research thus provides a practical new approach for the diagnosis and treatment of liver cancer."

基金机构：National Natural Science Foundation of China [21605046]; Natural Science Foundation of China (NSFC) [2017JJ3060]; Hunan Provincial Natural Science Foundation of China

基金资助正文："This work was supported by the Natural Science Foundation of China (NSFC, Grants 21605046) and the Hunan Provincial Natural Science Foundation of China (No. 2017JJ3060)."