PP2A drives the stemness in colorectal cancer cells by decreasing the Hippo signaling pathway

作者全名："Wang, Meng; Chen, Ting; Zhang, Jie; Wen, Xing"

作者地址："[Wang, Meng; Zhang, Jie; Wen, Xing] Southwest Jiaotong Univ, Ctr Gastrointestinal & Minimally Invas Surg, Peoples Hosp Chengdu 3, Dept Gen Surg,Affiliated Hosp, Chengdu 610031, Peoples R China; [Wang, Meng; Zhang, Jie; Wen, Xing] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China; [Chen, Ting] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Dept Anorectal, Affiliated Hosp, Chengdu 610031, Peoples R China; [Chen, Ting] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China"

通信作者："Wen, X (通讯作者)，Southwest Jiaotong Univ, Ctr Gastrointestinal & Minimally Invas Surg, Peoples Hosp Chengdu 3, Dept Gen Surg,Affiliated Hosp, Chengdu 610031, Peoples R China.; Wen, X (通讯作者)，Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China."

来源：CELLULAR AND MOLECULAR BIOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001185714600018

JCR分区：Q4

影响因子：1.5

年份：2023

卷号：69

期号：14

开始页：114

结束页：120

文献类型：Article

关键词：Cancer stem cell; CRC; Hippo pathway; Hsa-circ-001680; POLR2A; PP2A

摘要："Colorectal cancer (CRC) is one of the most prevalent malignancies. Accumulating evidence suggests that Hippo signaling pathway is a crucial signaling pathway that regulates stemness in multiple cancers, including CRC. Given that, the therapeutics targeting the Hippo pathway are of great interest. At the same time, previous studies have reported that PP2A regulates the Hippo pathway in tumorigenesis. In this study, we uncover the role of PP2A in vitro and in vivo and the interaction between PP2A and Hippo signaling pathway in CRC stemness. We investigate the molecular mechanism of PP2A-mediated Hippo pathway in CRC progression from the aspect of cell stemness. Furthermore, we explore the transcription factor of PP2A in CRC. In view of circRNA's regulation of cancer-related signaling pathways in CRC, we also study the association between PP2A-mediated Hippo pathway and the CRC-related circRNA (hsa-circ-001680) confirmed in previous studies. Of note, we demonstrate how hsa-circ-001680 regulates PP2A expression. The effect of hsa-circ-001680 on PP2A stability is investigated as well. In conclusion, the study demonstrates the mechanism of PP2A-mediated pathway on CRC stemness, which may provide new sights for the treatment of CRC. Copyright: (c) 2023 by the C.M.B. Association. All rights reserved."

基金机构：Science and Technology Project of the Health Planning Committee of Sichuan Province [21PJ147]

基金资助正文：The research is supported by: This study was funded by the Science and Technology Project of the Health Planning Committee of Sichuan Province (No. 21PJ147).