Reconfiguration of Structural and Functional Connectivity Coupling in Patient Subgroups With Adolescent Depression

作者全名：Xu, Ming; Li, Xuemei; Teng, Teng; Huang, Yang; Liu, Mengqi; Long, Yicheng; Lv, Fajin; Zhi, Dongmei; Li, Xiang; Feng, Aichen; Yu, Shan; Calhoun, Vince; Zhou, Xinyu; Sui, Jing

作者地址：[Sui, Jing] Beijing Normal Univ, 19 Xinwaidajie, Beijing 100875, Peoples R China; [Zhou, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Xu, Ming; Li, Xiang; Feng, Aichen; Yu, Shan] Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China; [Xu, Ming; Li, Xuemei; Feng, Aichen; Yu, Shan] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China; [Xu, Ming; Li, Xiang; Feng, Aichen; Yu, Shan] Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China; [Li, Xuemei; Teng, Teng; Zhou, Xinyu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Huang, Yang; Liu, Mengqi; Lv, Fajin] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Long, Yicheng] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China; [Long, Yicheng] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China; [Zhi, Dongmei; Sui, Jing] Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Int Data Grp IDG, Beijing, Peoples R China; [Calhoun, Vince] Emory Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci T, Atlanta, GA USA; [Calhoun, Vince] Georgia State Univ, Atlanta, GA USA

通信作者：Sui, J (通讯作者)，Beijing Normal Univ, 19 Xinwaidajie, Beijing 100875, Peoples R China.; Zhou, XY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing 400016, Peoples R China.

来源：JAMA NETWORK OPEN

ESI学科分类：　

WOS号：WOS:001185735800009

JCR分区：Q1

影响因子：10.5

年份：2024

卷号：7

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：Importance Adolescent major depressive disorder (MDD) is associated with serious adverse implications for brain development and higher rates of self-injury and suicide, raising concerns about its neurobiological mechanisms in clinical neuroscience. However, most previous studies regarding the brain alterations in adolescent MDD focused on single-modal images or analyzed images of different modalities separately, ignoring the potential role of aberrant interactions between brain structure and function in the psychopathology. Objective To examine alterations of structural and functional connectivity (SC-FC) coupling in adolescent MDD by integrating both diffusion magnetic resonance imaging (MRI) and resting-state functional MRI data. Design, Setting, and Participants This cross-sectional study recruited participants aged 10 to 18 years from January 2, 2020, to December 28, 2021. Patients with first-episode MDD were recruited from the outpatient psychiatry clinics at The First Affiliated Hospital of Chongqing Medical University. Healthy controls were recruited by local media advertisement from the general population in Chongqing, China. The sample was divided into 5 subgroup pairs according to different environmental stressors and clinical characteristics. Data were analyzed from January 10, 2022, to February 20, 2023. Main Outcomes and Measures The SC-FC coupling was calculated for each brain region of each participant using whole-brain SC and FC. Primary analyses included the group differences in SC-FC coupling and clinical symptom associations between SC-FC coupling and participants with adolescent MDD and healthy controls. Secondary analyses included differences among 5 types of MDD subgroups: with or without suicide attempt, with or without nonsuicidal self-injury behavior, with or without major life events, with or without childhood trauma, and with or without school bullying. Results Final analyses examined SC-FC coupling of 168 participants with adolescent MDD (mean [mean absolute deviation (MAD)] age, 16.0 [1.7] years; 124 females [73.8%]) and 101 healthy controls (mean [MAD] age, 15.1 [2.4] years; 61 females [60.4%]). Adolescent MDD showed increased SC-FC coupling in the visual network, default mode network, and insula (Cohen d ranged from 0.365 to 0.581; false discovery rate [FDR]-corrected P < .05). Some subgroup-specific alterations were identified via subgroup analyses, particularly involving parahippocampal coupling decrease in participants with suicide attempt (partial eta(2) = 0.069; 90% CI, 0.025-0.121; FDR-corrected P = .007) and frontal-limbic coupling increase in participants with major life events (partial eta(2 )ranged from 0.046 to 0.068; FDR-corrected P < .05). Conclusions and Relevance Results of this cross-sectional study suggest increased SC-FC coupling in adolescent MDD, especially involving hub regions of the default mode network, visual network, and insula. The findings enrich knowledge of the aberrant brain SC-FC coupling in the psychopathology of adolescent MDD, underscoring the vulnerability of frontal-limbic SC-FC coupling to external stressors and the parahippocampal coupling in shaping future-minded behavior.

基金机构：Scientific and Technological Innovation 2030 [2021ZD0200500, 2022ZD0212900]; Natural Science Foundation of China [82271565, 81873800, 82022035]; China Postdoctoral Science Foundation [2022M710434]; National Institute of Health grants [R01MH117107, R01MH118695]; National Science Foundation [2112455]

基金资助正文：This study was supported in part by grants 2021ZD0200500 (Dr Sui) and 2022ZD0212900(Dr Zhou) from the Scientific and Technological Innovation 2030; grants 82271565 (Dr Zhou), 81873800 (DrZhou), and 82022035 (Dr Sui) from the Natural Science Foundation of China; grant 2022M710434 from China Postdoctoral Science Foundation (Dr Zhi); grants R01MH117107 and R01MH118695 from the National Institute ofHealth grants (Dr Calhoun); and grant 2112455 from the National Science Foundation (Dr Calhoun).