Synthesis of <i>Pseudostellaria heterophylla</i> polysaccharide-gold nanocomposites and their antitumor effect through immunomodulation

作者全名："Liu, Zijing; Bao, Yixi; Lan, Haiyan; Pu, Youwei"

作者地址："[Liu, Zijing] Chongqing Med Univ, Affiliated Hosp 3, Dept Gastroenterol, Chongqing, Peoples R China; [Bao, Yixi; Lan, Haiyan; Pu, Youwei] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Lab, Chongqing, Peoples R China; [Pu, Youwei] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Lab, 76 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Pu, YW (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Lab, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：MICROSCOPY RESEARCH AND TECHNIQUE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001185907000001

JCR分区：Q2

影响因子：2

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：antitumor; gold nanoparticles; green synthesis; immune; polysaccharide; Pseudostellaria heterophylla

摘要："Polysaccharides from natural sources have an excellent immune function and low toxicity; however, their limitations such as short half-life and instability limit their sustained pharmacological activity. In this context, the combination of polysaccharides and nanotechnology have been developed to promote the stability and prolong the immune activities of polysaccharides. To synthesize and explore the antitumor effect and immunomodulatory activity of PHP-AuNPs. Polysaccharides extracted from Pseudostellaria heterophylla were used to synthesize gold nanocomposites (PHP-AuNPs), and their physicochemical properties and immunoregulatory effect in vitro and in vivo were analyzed. The PHP-AuNPs were green synthesized with high biosafety. PHP-AuNPs can activate macrophages in vitro and decrease the tumor weight and volume, whereas they increase the immune organ index in vivo. Besides, PHP-AuNPs showed a beneficial effect for maintaining the immune balance of CD4(+)/CD8(+) T cells and modulating the release of cytokines such as TNF-alpha increase and IL-10 decrease in mice. All these results suggested that PHP-AuNPs exhibit a remarkable antitumor effect and stronger immunomodulatory activity than that of free PHP-1."

基金机构：National Natural Science Foundation of China; Natural Science Foundation of Chongqing of China [cstc2021jcyj-msxmX0094]; [81773940]

基金资助正文：This work was supported by the Natural Science Foundation of Chongqing of China (No. cstc2021jcyj-msxmX0094) and the National Natural Science Foundation of China (No. 81773940).