"Prevalence, outcomes and associated factors of SARS-CoV-2 infection in psoriasis patients of Southwest China: a cross-sectional survey"

作者全名："Zou, Yang; Xu, Jing; Chen, Ai-Jun; Huang, Kun; Zhu, Shou-Min; Li, Jian-Jun; He, Jin; Li, Jun-Zhi; Xiong, Jian-Xia; Fan, Yu-Kun; Liu, Chuan; Pan, Yun; Wang, Ping"

作者地址："[Zou, Yang; Xu, Jing; Chen, Ai-Jun; Huang, Kun; Li, Jun-Zhi; Xiong, Jian-Xia; Liu, Chuan; Pan, Yun; Wang, Ping] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China; [Zhu, Shou-Min] Chongqing Three Gorges Med Coll, Peoples Hosp, Dept Dermatol, Chongqing, Peoples R China; [Li, Jian-Jun] Chongqing Univ, Qianjiang Hosp, Dept Dermatol, Chongqing, Peoples R China; [He, Jin] Peoples Hosp Kaizhou Dist, Dept Dermatol, Chongqing, Peoples R China; [Fan, Yu-Kun] Chongqing Med Univ, Affiliated Hosp 3, Dept Dermatol, Chongqing, Peoples R China"

通信作者："Wang, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001185967600030

JCR分区：Q1

影响因子：3.8

年份：2024

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："In this study we aimed to investigate the prevalence of SARS-CoV-2 infection in psoriasis patients, and outcomes of SARS-CoV-2 infection and associated risk factors. A cross-sectional survey was conducted from February 2023 to March 2023. Information was obtained with online questionnaire about psoriasis patients on demographic characteristics, clinical characteristics, SARS-CoV-2 infection and outcomes, vaccination, and routine protection against COVID-19. Logistic regression analysis was used to explore risk factors with SARS-CoV-2 infection and exacerbation of psoriasis. A total of 613 participants were recruited. 516 (84.2%) were infected, and associated factors were sex, working status, routine protection against COVID-19, COVID-19 vaccination, impaired nail, infection exacerbate psoriasis, and severity of psoriasis. Among the patients infected with SARS-CoV-2, 30 (5.8%) required hospitalization, 122 (23.6%) had psoriasis exacerbation due to SARS-CoV-2 infection, and associated factors were subtype of psoriasis, discontinuation of psoriasis treatment during SARS-CoV-2 infection, response following COVID-19 vaccination, and severity of psoriasis. Booster dose vaccination contributed a low probability of COVID-19 sequelae. COVID-19 vaccine's effectiveness was unsatisfactory, while booster dose vaccination reduced the occurrence of COVID-19 sequelae in psoriasis patients of Southwest China. Patients treated with psoriasis shown to be safe, without a higher incidence of SARS-CoV-2 infection or COVID-19hospitalization compared to untreated patients. Stopping treatment during SARS-CoV-2 infection led to psoriasis exacerbation, so psoriasis treatment could be continued except severe adverse reaction."

基金机构：National natural science foundation of China [NSFC 82103733]; Chongqing Health Commission [2022QNXM048]; Science and Technology Bureau [2022QNXM048]

基金资助正文：National natural science foundation of China: grant number NSFC 82103733; Joint project of Chongqing Health Commission and Science and Technology Bureau: grant number 2022QNXM048.