Imaging Transcriptomics of the Brain for Schizophrenia

作者全名："Gu, Yue-Wen; Fan, Jing-Wen; Zhao, Hongyi; Zhao, Shu-Wan; Liu, Xiao-Fan; Yu, Renqiang; Ren, Lei; Wang, Xinjiang; Yin, Hong; Cui, Long-Biao"

作者地址："[Gu, Yue-Wen; Fan, Jing-Wen; Zhao, Shu-Wan; Liu, Xiao-Fan; Ren, Lei; Cui, Long-Biao] Air Force Med Univ, Dept Clin Psychol, Xian, Peoples R China; [Gu, Yue-Wen; Fan, Jing-Wen; Zhao, Shu-Wan; Yin, Hong] Air Force Med Univ, Xijing Hosp, Dept Radiol, Xian, Peoples R China; [Zhao, Hongyi] 984 Hosp PLA, Dept Neurol, Beijing, Peoples R China; [Yu, Renqiang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Wang, Xinjiang; Cui, Long-Biao] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Radiol, Beijing, Peoples R China; [Yin, Hong] Xian Peoples Hosp, Xian Hosp 4, Dept Radiol, Xian, Peoples R China"

通信作者："Cui, LB (通讯作者)，Air Force Med Univ, Dept Clin Psychol, Xian, Peoples R China.; Yin, H (通讯作者)，Air Force Med Univ, Xijing Hosp, Dept Radiol, Xian, Peoples R China.; Wang, XJ; Cui, LB (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Radiol, Beijing, Peoples R China.; Yin, H (通讯作者)，Xian Peoples Hosp, Xian Hosp 4, Dept Radiol, Xian, Peoples R China."

来源：ALPHA PSYCHIATRY

ESI学科分类：　

WOS号：WOS:001186217900010

JCR分区：Q4

影响因子：0.7

年份：2024

卷号：25

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Schizophrenia; transcriptomics; magnetic resonance imaging

摘要："Schizophrenia is a severe mental disorder with a neurodevelopmental origin. Although schizophrenia results from changes in the brain, the underlying biological mechanisms are unknown. Transcriptomics studies quantitative expression changes or qualitative changes of all genes and isoforms, providing a more meaningful biological insight. Magnetic resonance imaging (MRI) techniques play roles in revealing brain structure and function. We give a narrative focused review on the current transcriptome combined with MRI studies related to schizophrenia and summarize the research methodology and content of these studies to identify the research commonalities as well as the implications for future research, in an attempt to provide new insights into the mechanism, clinical diagnosis, and treatments of schizophrenia."

基金机构：National Natural Science Foundation of China [82271949]; China Postdoctoral Science Foundation [2020M683739]; Fourth Military Medical University [2019CYJH]

基金资助正文："Funding: This work was supported by the project funded by the National Natural Science Foundation of China (General Program) , (Grant number: 82271949) ; China Postdoctoral Science Foundation (Grant number: 2020M683739; and the Fourth Military Medical University (Grant number: 2019CYJH) ."