Multifunctional nanocomposites mediated novel hydrogel for diabetic wound repair

作者全名："Zhou, Yingjuan; Yang, Jiaxin; Li, Yan; Shu, Xin; Cai, Yucen; Xu, Ping; Huang, Wenyan; Yang, Zhangyou; Li, Rong"

作者地址："[Zhou, Yingjuan; Cai, Yucen; Xu, Ping; Huang, Wenyan; Yang, Zhangyou] Chongqing Med Univ, Coll Pharm, Ctr Pharmaceut Formulat & Nanomed Res, Chongqing 400016, Peoples R China; [Yang, Jiaxin; Li, Rong] Army Med Univ, Inst Combined Injury, State Key Lab Trauma Burns & Combined Injury, Mil Key Lab Nanomed,Dept Mil Prevent Med, Chongqing 400038, Peoples R China; [Li, Yan] Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing 401331, Peoples R China; [Shu, Xin] Coll Pharm, Chongqing Med & Pharmaceut Coll, Chongqing, Peoples R China"

通信作者："Yang, ZY (通讯作者)，Chongqing Med Univ, Coll Pharm, Ctr Pharmaceut Formulat & Nanomed Res, Chongqing 400016, Peoples R China.; Li, R (通讯作者)，Army Med Univ, Inst Combined Injury, State Key Lab Trauma Burns & Combined Injury, Mil Key Lab Nanomed,Dept Mil Prevent Med, Chongqing 400038, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001187094900001

JCR分区：Q1

影响因子：6.1

年份：2024

卷号：12

期号：13

开始页：3292

结束页：3306

文献类型：Article

关键词：　

摘要："The regeneration and repair of diabetic wounds, especially those including bacterial infection, have always been difficult and challenging using current treatment. Herein, an effective strategy is reported for constructing glucose-responsive functional hydrogels using nanocomposites as nodes. In fact, tannic acid (TA)-modified ceria nanocomposites (CNPs) and a zinc metal-organic framework (ZIF-8) were employed as nodes. Subsequent crosslinking with 3-acrylamidophenylboronic acid achieved functional nanocomposite-hydrogels (TA@CN gel, TA@ZMG gel) by radical-mediated polymerization. Compared with a simple physically mixed hydrogel system, the mechanical properties of TA@CN gel and TA@ZMG gel are significantly enhanced due to the intervention of the nanocomposite nodes. In addition, this kind of nanocomposite hydrogel can realize the programmed loading of drugs and release of drugs in response to glucose/PH, to coordinate and promote its application in the regeneration and repair of diabetic wounds and infected diabetic wounds. Specifically, TA@CN gel can remove reactive oxygen species and generate oxygen through its various enzymatic activities. At the same time, it can effectively promote neovascularization, thus promoting the regeneration and repair of diabetic wounds. Furthermore, glucose oxidase-loaded TA@ZMG gel exhibits glucose response and pH-regulating functions, triggering programmed metformin (Met) release by degrading the metal-organic framework (MOF) backbone. It also exhibited additional synergistic effects of antibacterial activity, hair regeneration and systemic blood glucose regulation, which make it suitable for the repair of more complex infected diabetic wounds. Overall, this novel nanocomposite-mediated hydrogel holds great potential as a biomaterial for the healing of chronic diabetic wounds, opening up new avenues for further biomedical applications. Synthesis strategy of glucose-responsive intelligent hydrogels based on multifunctional nanocomposite nodes and their mechanism in diabetic and infected diabetic wounds."

基金机构：National Natural Science Foundation of China [82173456]; National Natural Science Foundation of China [CSTC2021jcyj-msxm3803]; Chongqing Municipal Foundation [CSTB2022NSCQ-MSX1084]; Natural Science Foundation of Chongqing

基金资助正文："Yingjuan Zhou, Jiaxin Yang and Yan Li contributed equally to this work. This work was supported by the National Natural Science Foundation of China (No. 82173456), Chongqing Municipal Foundation (CSTC2021jcyj-msxm3803), and the Natural Science Foundation of Chongqing (Grant No. CSTB2022NSCQ-MSX1084)."