Additively manufactured bioceramic scaffolds with 3D architecture for vertical bone augmentation: A proof-of-concept study

作者全名："Liu, Wei; Zheng, Lingling; Wang, Chao; Yin, Hubin; Raffaella, Aversa; Apicella, Antonio; Ji, Ping; Zhang, Hongmei; Fan, Yubo"

作者地址："[Liu, Wei; Ji, Ping; Zhang, Hongmei] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Liu, Wei; Ji, Ping; Zhang, Hongmei] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Zheng, Lingling; Wang, Chao; Yin, Hubin; Fan, Yubo] Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol,Minist Educ,Sch Engn, Beijing 100083, Peoples R China; [Raffaella, Aversa; Apicella, Antonio] Univ Campania, Adv Mat Lab, I-81031 Caserta, Italy; [Liu, Wei; Ji, Ping; Zhang, Hongmei] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China"

通信作者："Zhang, HM (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China.; Wang, C (通讯作者)，Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol,Minist Educ,Sch Engn, Beijing 100083, Peoples R China."

来源：MATERIALS & DESIGN

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001188601500001

JCR分区：Q1

影响因子：7.6

年份：2024

卷号：239

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Vertical bone augmentation; Additively manufactured; Bioceramics scaffold; 3D architectures; Bone regeneration

摘要："Vertical bone augmentation remains a significant challenge in implant dentistry and orofacial surgery, which is aimed at regenerating bone extraskeletal. This study conducts a proof-of-concept investigation into the effects of additively manufactured bioceramic scaffolds featuring bioinspired 3D architectures (trabecular, open channel, and layered) on vertical bone augmentation from the perspectives of osteogenesis and biomechanics. The experimental scaffold design was categorized into 4 Groups. Compression tests and finite element analysis (FEA) were conducted to assess the mechanical properties of scaffolds, Computational Fluid Dynamics (CFD) was employed to evaluate permeability and wall shear stress in scaffolds. Subsequently, the osteogenesis and biomechanical properties of these scaffolds were systematically evaluated in vivo using a rabbit calvarium model. The results illustrated that compression strength for all groups was within the typical range of trabecular bone. Remarkable bone neoformation was observed around the lower half of the scaffold, establishing a strong osseointegration effect with both the calvaria bone and scaffolds, and the highest osteogenic growth (approximately 4 mm) was observed at the interface between the titanium screw and the scaffold. This study scientifically proves that DLP-based bioceramic scaffolds effectively fulfill the osteogenic and biomechanical prerequisites for vertical bone augmentation, thereby providing preliminary validation of this concept."

基金机构："National Natural Science Foundation of China [12072055, 11872135, U20A20390]; Natural Science Foundation of Beijing [L212063]; Fundamental Research Funds for the Central Universities; The 111 Project [B13003]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2019-I2M-5-016]; Belt and Road Innovative Talent Exchange Program for Foreign Experts of the State Administration of Foreign Experts Affairs [DL2023177001L]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (Grant Nos. 12072055, 11872135, U20A20390) , Natural Science Foundation of Beijing (Grant No. L212063) and the Fundamental Research Funds for the Central Universities, the 111 Project (No. B13003) , CAMS Innovation Fund for Medical Sciences (CIFMS) under Grant 2019-I2M-5-016, ""Belt and Road"" Innovative Talent Exchange Program for Foreign Experts of the State Administration of Foreign Experts Affairs (No. DL2023177001L) ."