Pyroptosis: The Determinator of Cell Death and Fate in Acute Kidney Injury

作者全名："Xiong, Jiachuan; Zhao, Jinghong"

作者地址："[Xiong, Jiachuan; Zhao, Jinghong] Third Mil Med Univ, Dept Nephrol, Key Lab Prevent & Treatment Chron Kidney Dis Chong, Kidney Ctr PLA,Xinqiao Hosp,Army Med Univ, Chongqing, Peoples R China"

通信作者："Zhao, JH (通讯作者)，Third Mil Med Univ, Dept Nephrol, Key Lab Prevent & Treatment Chron Kidney Dis Chong, Kidney Ctr PLA,Xinqiao Hosp,Army Med Univ, Chongqing, Peoples R China."

来源：KIDNEY DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001189613800001

JCR分区：Q1

影响因子：3.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Treatment; Acute kidney injury; Pyroptosis; Mechanism

摘要："Background: Acute kidney injury (AKI) is kidney damage that leads to a rapid decline in function. AKI primarily occurs when the tubular epithelium is damaged, causing swelling, loss of brush margin, and eventual apoptosis. Research has shown that tubular epithelial cell damage in AKI is linked to cell cycle arrest, autophagy, and regulation of cell death. Summary: Pyroptosis, a type of programmed cell death triggered by inflammation, is believed to play a role in the pathophysiology of AKI. Cumulative evidence has shown that pyroptosis is the main cause of tubular cell death in AKI. Thus, targeted intervention of pyroptosis may be a promising therapeutic approach for AKI. This review delves deep into the cutting-edge research surrounding pyroptosis in the context of AKI, shedding light on its intricate mechanisms and potential implications for clinical practice. Additionally, we explore the exciting realm of potential preclinical treatment options for AKI, aiming to pave the way for future therapeutic advancements. Key Messages: Pyroptosis, a highly regulated form of cell death, plays a crucial role in determining the fate of cells during the development of AKI. This intricate process involves the activation of inflammasomes, which are multi-protein complexes that initiate pyroptotic cell death. By understanding the mechanisms underlying pyroptosis, researchers aim to gain insights into the pathogenesis of AKI and potentially identify new therapeutic targets for this condition."

基金机构：Key program of the Natural Science Foundation of China [82030023]; Joint Funds of the National Natural Science Foundation of China [U22A20279]; Frontier-specific projects of Xinqiao Hospital [2018YQYLY004]; Personal training Program for Clinical Medicine Research of Army Medical University [2018XLC1007]

基金资助正文："This work was supported by the Key program of the Natural Science Foundation of China (No. 82030023), Joint Funds of the National Natural Science Foundation of China (No. U22A20279),Frontier-specific projects of Xinqiao Hospital (No. 2018YQYLY004), and Personal training Program for Clinical Medicine Research of Army Medical University (No. 2018XLC1007)."