Recent advances of myotubularin-related (MTMR) protein family in cardiovascular diseases

作者全名："Wang, Jia; Guo, Wei; Wang, Qiang; Yang, Yongjian; Sun, Xiongshan"

作者地址："[Wang, Jia; Wang, Qiang; Yang, Yongjian; Sun, Xiongshan] Gen Hosp Western Theater Command, Dept Cardiol, Chengdu, Sichuan, Peoples R China; [Wang, Jia; Wang, Qiang] Southwest Jiaotong Univ, Coll Med, Chengdu, Sichuan, Peoples R China; [Guo, Wei] Chongqing Med Univ, Clin Res Ctr, Stomatol Hosp, Chongqing, Peoples R China"

通信作者："Yang, YJ; Sun, XS (通讯作者)，Gen Hosp Western Theater Command, Dept Cardiol, Chengdu, Sichuan, Peoples R China."

来源：FRONTIERS IN CARDIOVASCULAR MEDICINE

ESI学科分类：　

WOS号：WOS:001189657700001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：cardiovascular diseases; MTMR; phosphoinositide; PI3K/AKT; autophagy

摘要："Belonging to a lipid phosphatase family containing 16 members, myotubularin-related proteins (MTMRs) are widely expressed in a variety of tissues and organs. MTMRs preferentially hydrolyzes phosphatidylinositol 3-monophosphate and phosphatidylinositol (3,5) bis-phosphate to generate phosphatidylinositol and phosphatidylinositol 5-monophosphate, respectively. These phosphoinositides (PIPs) promote membrane degradation during autophagosome-lysosomal fusion and are also involved in various regulatory signal transduction. Based on the ability of modulating the levels of these PIPs, MTMRs exert physiological functions such as vesicle trafficking, cell proliferation, differentiation, necrosis, cytoskeleton, and cell migration. It has recently been found that MTMRs are also involved in the occurrence and development of several cardiovascular diseases, including cardiomyocyte hypertrophy, proliferation of vascular smooth muscle cell, LQT1, aortic aneurysm, etc. This review summarizes the functions of MTMRs and highlights their pathophysiological roles in cardiovascular diseases."

基金机构：International Natural Science Foundation

基金资助正文：No Statement Available