"EXPRESSION LEVELS AND DIAGNOSTIC VALUE OF SERUM GDNF, CEA AND CA199 IN PATIENTS WITH COLORECTAL CARCINOMA"

作者全名："Wang, Jue; Liu, Lulu; Zheng, Yan; Gu, Sai"

作者地址："[Wang, Jue; Liu, Lulu; Zheng, Yan; Gu, Sai] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Gu, Sai] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Gu, S (通讯作者)，Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China."

来源：JOURNAL OF MEDICAL BIOCHEMISTRY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001189945300002

JCR分区：Q4

影响因子：2

年份：2024

卷号：43

期号：2

开始页：250

结束页：256

文献类型：Article

关键词：GDNF; CEA; CA199; colorectal carcinoma (CRC); diagnostic value

摘要："Background: To investigate the expression levels and diagnostic value of glial cell line -derived neurotrophic factor (GDNF), carcinoembryonic antigen (CEA) and carbohydrate antigen199 (CA199) in patients with colorectal carcinoma (CRC). Methods: 50 CRC patients at our hospital from Feb. 2020 to Feb. 2021 were chosen as the malignant group, another 50 patients with benign colonic diseases were chosen as the benign group, and 50 healthy people who came to our hospital for physical examination during the same period were considered as the control group. Fasting peripheral venous blood was taken from all research subjects in the morning and tested by a fully -automated electrochemiluminometer to determine the GDNF, CEA and CA199 levels. The sensitivity and specificity of the combined detection of the three indexes for CRC were analyzed, and the receiver operating characteristic (ROC) curve was plotted to record the area under the curve (AUC). Results: The malignant group had remarkably higher CEA and CA199 levels (P<0.001) and a lower GDNF level (P<0.001) when compared with the benign and control groups. The sensitivity, specificity, positive predictive value and negative predictive value of the combined detection were 96.0%, 94.0%, 88.9% and 97.9%, respectively. Under combined detection, AUC (95% CI) = 0.950 (0.909-0.991), standard error = 0.021, and P<0.001. Conclusions: The combined diagnosis of serum GDNF, CEA and CA199 is a reliable method to improve the diag nostic accuracy of CRC, and this strategy can effectively reduce the missed diagnosis rate and has high application value in clinic."

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