Research Advances in Neuroblast Migration in Traumatic Brain Injury

作者全名："Wu, Na; Li, Wenlang; Chen, Qiang; Chen, Meng; Chen, Siyuan; Cheng, Chongjie; Xie, Yimin"

作者地址："[Wu, Na; Chen, Qiang; Chen, Meng; Chen, Siyuan; Xie, Yimin] Chongqing Univ, Dept Pediat Surg, Three Gorges Hosp, 165 Xincheng Rd, Chongqing 404100, Peoples R China; [Cheng, Chongjie] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Wenlang] Chongqing Med Univ, Dept Anesthesiol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Xie, YM (通讯作者)，Chongqing Univ, Dept Pediat Surg, Three Gorges Hosp, 165 Xincheng Rd, Chongqing 404100, Peoples R China."

来源：MOLECULAR NEUROBIOLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001190106700001

JCR分区：Q1

影响因子：4.6

年份：2024

卷号：　

期号：　

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文献类型：Review; Early Access

关键词：Neuroblast migration; Traumatic brain injury; Neurogenesis; Neuronal migration; Vascular migration

摘要："Neuroblasts were first derived from the adult mammalian brains in the 1990s by Reynolds et al. Since then, persistent neurogenesis in the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) has gradually been recognized. To date, reviews on neuroblast migration have largely investigated glial cells and molecular signaling mechanisms, while the relationship between vasculature and cell migration remains a mystery. Thus, this paper underlines the partial biological features of neuroblast migration and unravels the significance and mechanisms of the vasculature in the process to further clarify theoretically the neural repair mechanism after brain injury. Neuroblast migration presents three modes according to the characteristics of cells that act as scaffolds during the migration process: gliophilic migration, neurophilic migration, and vasophilic migration. Many signaling molecules, including brain-derived neurotrophic factor (BDNF), stromal cell-derived factor 1 (SDF-1), vascular endothelial growth factor (VEGF), and angiopoietin-1 (Ang-1), affect vasophilic migration, synergistically regulating the migration of neuroblasts to target areas along blood vessels. However, the precise role of blood vessels in the migration of neuroblasts needs to be further explored. The in-depth study of neuroblast migration will most probably provide theoretical basis and breakthrough for the clinical treatment of brain injury diseases."

基金机构：National Natural Science Foundation of China

基金资助正文："We thank Professor Yan Wang (Chongqing Medical University, China) for proofreading this paper."