Intra-Articular Injection of Interleukin-8 Neutralizing Monoclonal Antibody Effectively Attenuates Osteoarthritis Progression in Rabbits

作者全名："Yang, Junjun; Wang, Xin; Zhang, Yingbo; He, Rui; Fu, Zhenlan; Wang, Rong; Ma, Yanming; Fu, Dejie; Meng, Shuo; Cai, Wang; Zhou, Yizhao; Chen, Cheng; Chen, Guangxing; Gong, Xiaoyuan"

作者地址："[Yang, Junjun; Wang, Xin; He, Rui; Fu, Zhenlan; Wang, Rong; Ma, Yanming; Fu, Dejie; Cai, Wang; Chen, Guangxing; Gong, Xiaoyuan] Army Med Univ, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China; [Yang, Junjun] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing, Peoples R China; [Zhang, Yingbo] Yes Biotech Labs Ltd, Xuzhou, Jiangsu, Peoples R China; [Meng, Shuo; Chen, Cheng] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China; [Zhou, Yizhao] Hunan Normal Univ, Hunan Prov Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, Changsha, Peoples R China; [Chen, Guangxing; Gong, Xiaoyuan] Army Med Univ, Southwest Hosp, Ctr Joint Surg, Chongqing 400038, Peoples R China; [Chen, Cheng] Chongqing Med Univ, Coll Med informat, Chongqing 400016, Peoples R China"

通信作者："Chen, GX; Gong, XY (通讯作者)，Army Med Univ, Southwest Hosp, Ctr Joint Surg, Chongqing 400038, Peoples R China.; Chen, C (通讯作者)，Chongqing Med Univ, Coll Med informat, Chongqing 400016, Peoples R China."

来源：CARTILAGE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001190168700001

JCR分区：Q1

影响因子：2.7

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：osteoarthritis; interleukin-8; monoclonal antibodies

摘要："Objective Cytokines are implicated in the pathogenesis of osteoarthritis (OA), and this study aims to assess the therapeutic potential of an IL-8 neutralizing monoclonal antibody (mAb) for OA intervention.Design The study employed a rabbit model of OA induced by anterior cruciate ligament transection (ACLT) surgery to investigate the effects of an interleukin (IL)-8 neutralizing mAb, with hyaluronic acid (HA) used as a positive control. Primary outcomes assessed in the rabbits included cartilage repair, synovitis, joint effusion, changes in footprints, and lower limb loading conditions.Results Compared to HA, intra-articular injection of the IL-8 neutralizing mAb demonstrated a more pronounced attenuation of OA progression and enhancement of cartilage repair. We observed a reduction in synovitis and joint effusion, indications of bone marrow edema, as well as improvements in lower limb function. In knees treated with the neutralizing IL-8 mAb, there was a significant decrease in IL-8 levels within the synovial tissues.Conclusions The IL-8 neutralizing mAb exhibits promising therapeutic potential in the management of OA by attenuating inflammation and facilitating cartilage repair. However, further investigations are warranted to comprehensively elucidate the underlying mechanisms, optimize treatment protocols, and ensure the long-term safety and efficacy of this innovative therapeutic approach."

基金机构："Chongqing Natural Science Foundation General Project [cstc2021jcyj-msxmX0135, CSTB2022NSCQ-MSX0139]; Chongqing Natural Science Foundation Innovation Development Joint Fund (Municipal Education Commission) Project [2022NSCQ-LZX0256]; Natural Science Foundation of Hunan Province [2021JJ304060]; Chongqing Postdoctoral Research Project Special Fund [2021XM3033]"

基金资助正文："The authors extend their gratitude to Yes Biotech Laboratories Ltd. for their generous donation of IL-8 Neutralizing mAb for our research. They also thank Kunming Baker Norton Pharmaceutical for providing Hyaluronic Acid (HA, ARTZ (R) Dispo, Imported Drug License: H20140533). Besides, they express their appreciation to Chongqing Yinglian Medical Imaging Diagnosis Center Co., Ltd. for their invaluable provision of MRI scanning services. In addition, they are grateful to Knorigene Technologies for their technical support in histologic staining. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Chongqing Natural Science Foundation General Project (grant nos. cstc2021jcyj-msxmX0135 and CSTB2022NSCQ-MSX0139), Chongqing Natural Science Foundation Innovation Development Joint Fund (Municipal Education Commission) Project (grant no. 2022NSCQ-LZX0256), Natural Science Foundation of Hunan Province (grant no. 2021JJ304060) and Chongqing Postdoctoral Research Project Special Fund (grant no. 2021XM3033)."