Efficacy and Safety of Anhydrous Ethanol-Assisted Endoscopic Ultrasound-Guided Transluminal Necrosectomy in Infected Necrotizing Pancreatitis

作者全名："Zeng, Yan; Zhang, Jun-Wen; Yang, Jian"

作者地址："[Zeng, Yan] Chongqing Med Univ, Affiliated Hosp 2, Dept Psychol, Chongqing 400010, Peoples R China; [Zhang, Jun-Wen; Yang, Jian] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Yang, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：DIGESTIVE DISEASES AND SCIENCES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001190313600003

JCR分区：Q2

影响因子：2.5

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Anhydrous ethanol; Endoscopic transluminal necrosectomy; Endoscopic ultrasound; Infected necrotizing pancreatitis; Efficacy; Safety

摘要："AimEndoscopic necrosectomy has become the first-line treatment option for infectious necrotizing pancreatitis (INP), especially walled-off necrosis. However, the problems, including operation-related adverse events (AEs) and the need for multiple endoscopic procedures, have not been effectively addressed. We sought to evaluate the clinical safety and efficacy of anhydrous ethanol-assisted endoscopic ultrasound (EUS)-guided transluminal necrosectomy in INP.MethodsA single-center observational cohort study of INP patients was conducted in a tertiary endoscopic center. Anhydrous ethanol-assisted EUS-guided transluminal necrosectomy (modified group) and conventional endoscopic necrosectomy (conventional group) were retrospectively compared in INP patients. The technical and clinical success rates, operation time, perioperative AEs, postoperative hospital stay, and recurrent INP rates were analyzed, respectively.ResultsA total of 55 patients were enrolled. No statistically significant differences were observed between the two groups regarding baseline characteristics. Compared to patients in the conventional group, patients in the modified group demonstrated significantly reduced times of endoscopic transluminal necrosectomies (1.96 +/- 0.89 vs. 2.73 +/- 0.98; P = 0.004) and comparable perioperative AEs (P = 0.35). Meanwhile, no statistically significant differences were observed in the technical and clinical success rates (P = 0.92), operation time (P = 0.59), postoperative hospital stay (P = 0.36), and recurrent INP rates (P = 1.00) between the two groups.ConclusionAnhydrous ethanol-assisted EUS-guided transluminal necrosectomy seemed safe and effective in treating INP. Compared with conventional endoscopic transluminal necrosectomy, its advantage was mainly in reducing the number of endoscopic necrosectomies without increasing perioperative AEs."

基金机构："Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University [CMER202305]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0138]"

基金资助正文："This study was supported by Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University (CMER202305) and Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0138)."