Red/NIR-I-Fluorescence Carbon Dots Based on Rhein with Active Oxygen Scavenging and Colitis Targeting for UC Therapeutics

作者全名："Xia, Jiashan; Wang, Jiayu; Liu, Fengyuan; Chen, Zhiqiong; Chen, Changmei; Cheng, Xiangshu; Chao, Yu; Wang, Yue; Deng, Tao"

作者地址："[Xia, Jiashan; Liu, Fengyuan; Chen, Zhiqiong; Chen, Changmei; Cheng, Xiangshu; Chao, Yu; Deng, Tao] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Wang, Jiayu] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Dept Pharm, Chongqing 401147, Peoples R China; [Chao, Yu; Deng, Tao] Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 400016, Peoples R China; [Chao, Yu; Deng, Tao] Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Wang, Yue] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Chao, Y; Deng, T (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China.; Chao, Y; Deng, T (通讯作者)，Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 400016, Peoples R China.; Chao, Y; Deng, T (通讯作者)，Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China.; Wang, Y (通讯作者)，Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001190398500001

JCR分区：Q1

影响因子：10

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：bioimaging; carbon dots; rhein; therapeutic efficacy; ulcerative colitis

摘要："Ulcerative colitis (UC) is a chronic inflammatory disease with uncontrolled inflammation and demage to the intestinal barrier. Rhein, a bioactive compound in traditional Chinese medicine, has anti-inflammatory and intestinal repair effect. However, their clinical application is limited by their hydrophobicity and poor bioavailability. L-arginine, as a complement to NO, has synergistic and attenuating effects. In this paper, red/NIR-I fluorescent carbon dots based on rhein and doped with L-arginine (RA-CDs), which are synthesized by a hydrothermal process without any organic solvents, are reported. RA-CDs preserve a portion of the functional group of the active precursor, increase rhein solubility, and emit red/NIR-I light for biological imaging. In vitro experiments show that RA-CDs scavenge excessive reactive oxygen species (ROS), protect cells from oxidative stress, and enable the fluorescence imaging of inflamed colons. In a DSS-induced UC mouse model, both delayed and prophylactic treatment with RA-CDs via intraperitoneal and tail vein injections alleviate UC severity by reducing intestinal inflammation and restoring the intestinal barrier. This study highlights a novel strategy for treating and imaging UC with poorly soluble small-molecule drugs. Ulcerative colitis (UC) is a chronic inflammatory illness marked by immunological dysfunction and intestinal damage. The current work describes the synthesis of RA-CDs, which improves rhein solubility and route of administration, increases the effectiveness of rhein and NO supplementation, and allows for biological imaging. RA-CDs demonstrate ROS scavenging and cytoprotective properties, and decrease the severity of UC in mice. image"

基金机构：China Postdoctoral Science Foundation; Future Medical Youth Innovation Team Support Program of Chongqing Medical University [W0090]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0849]; Chongqing Postdoctoral Science Foundation [2022NSCQ-BHX1294]; Chongqing Postdoctoral Special Support Foundation [2022CQBSHTB3008]; [2022MD713715]

基金资助正文："J.X., J.W., and F.L. contributed equally to this work. This work was financially supported by Future Medical Youth Innovation Team Support Program of Chongqing Medical University (W0090), Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0849), China Postdoctoral Science Foundation (2022MD713715) and Chongqing Postdoctoral Science Foundation (2022NSCQ-BHX1294), the Chongqing Postdoctoral Special Support Foundation (Grant No. 2022CQBSHTB3008)."