Identification and validation of neutrophils-related subtypes and prognosis model in triple negative breast cancer

作者全名："Li, Shanqi; Qian, Yuzhou; Xie, Wanchen; Li, Xinyu; Wei, Jiaying; Wang, Long; Ren, Guosheng; Yin, Xuedong"

作者地址："[Li, Shanqi; Xie, Wanchen; Li, Xinyu; Ren, Guosheng; Yin, Xuedong] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China; [Qian, Yuzhou] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Qian, Yuzhou; Ren, Guosheng] Chongqing Med Univ, Affiliated Hosp 1, Key Lab Mol Oncol & Epigenet, Chongqing, Peoples R China; [Wang, Long] Chongqing Univ, Canc Hosp, Dept Breast Canc Ctr, Chongqing, Peoples R China; [Wei, Jiaying] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China"

通信作者："Ren, GS; Yin, XD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China.; Ren, GS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Key Lab Mol Oncol & Epigenet, Chongqing, Peoples R China."

来源：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001190600700001

JCR分区：Q3

影响因子：2.7

年份：2024

卷号：150

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：Neutrophil; Triple-negative breast cancer; Immunotherapy; Tumor microenvironment; Tumor mutation burden

摘要："Background Neutrophils are considered to be crucial players in the initiation and progression of cancer. However, the complex relationship between neutrophils and cancer prognosis remains elusive, mainly due to the significant plasticity and diversity exhibited by these immune cells.Methods As part of our thorough investigation, we examined 38 Neutrophils-Related Genes (NRGs) and the associated copy number variations (CNV), somatic mutations, and gene expression patterns in relation to triple negative breast cancer (TNBC). The interactions between these genes, their biological roles, and their possible prognostic significance were then examined. With the NRGs as our basis, we applied Lasso and Cox regression analyses to create a predictive model for overall survival (OS). Furthermore, TNBC tissue and a public database were used to assess changes in MYO1D expression (MYO1D is characterized as a member of the myosin-I family, a group of motor proteins based on actin), its connection to neutrophil infiltration, and the clinical importance of MYO1D in TNBC.Results Four neutrophil-related genes were included in the development of a prognostic model based on neutrophils. The model was further shown to be an independent predicted factor for overall survival by multivariate Cox regression analysis. According to this study, neutrophil subtype B as well as gene subtype B, were associated with activated cancer immunity and poor prognosis of TNBC patients. Furthermore, considering that poor OS was linked to increased MYO1D expression, MYO1D was increased in TNBC tissues and associated with neutrophil infiltration. In vitro experiments also confirmed that MYO1D facilitates breast cancer invasion and metastasis.Conclusion Based on the degree of gene expression linked to neutrophils, a unique prognostic model was created. MYO1D could be a potential prognostic biomarker in TNBC patients and also a prospective target for therapy."

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