Omentin-1 ameliorates pulmonary arterial hypertension by inhibiting endoplasmic reticulum stress through AMPKα signaling

作者全名："Deng, Xinyu; Luo, Hao; He, Jing; Deng, Wang; Wang, Daoxin"

作者地址："[Deng, Xinyu; He, Jing; Deng, Wang; Wang, Daoxin] Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Luo, Hao] Third Mil Med Univ, Army Med Univ, Daping Hosp, Dept Cardiol, Chongqing, Peoples R China"

通信作者："Wang, DX (通讯作者)，Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL HYPERTENSION

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001190892800001

JCR分区：Q3

影响因子：1.5

年份：2024

卷号：46

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Omentin-1; pulmonary arterial hypertension; endoplasmic reticulum stress; AMPK; endothelial function

摘要："BackgroundEndothelial dysfunction of the pulmonary artery contributes to hypoxia-induced pulmonary arterial hypertension (PAH). Omentin-1, as a novel adipocytokine, plays an important protective role against cardiovascular diseases. However, the effect and underlying mechanisms of omentin-1 against PAH remain unclear.MethodsPAH was induced in SD (Sprague & Dawley) rats via a low-oxygen chamber for 4 weeks. Hemodynamic evaluation was undertaken using a PowerLab data acquisition system, and histopathological analysis was stained with hematoxylin and eosin (H&E). Endothelial function of pulmonary artery was assessed using wire myography.ResultsWe found that omentin-1 significantly improved pulmonary endothelial function in rats exposed to hypoxia and attenuated PAH. Mechanistically, we found that omentin-1 increased phosphorylated 5'-adenosine monophosphate-activated protein kinase (p-AMPK) level and reduced endoplasmic reticulum (ER) stress and increased NO production in pulmonary artery from rats exposed to hypoxia. However, the effect of omentin-1 was abolished by treatment with AMPK inhibitor (Compound C).ConclusionsOur results reveal a protective effect of omentin-1 in PAH via inhibiting ER stress through AMPK alpha signaling and provide an agent with translational potential for the treatment of PAH."

基金机构：National Natural Science Foundation of China [82270091]; Chongqing Talents: Exceptional Young Talents Project [CQYC202105046/cstc2022ycjh- bgzxm0106]

基金资助正文：No Statement Available