Immune microenvironment of human papillomavirus-positive head and neck squamous cell carcinoma

作者全名："Zhu, Dong; He, Xiang; Li, Yu; Li, Guoping; Chen, Min"

作者地址："[Zhu, Dong; Li, Yu; Li, Guoping; Chen, Min] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China; [Zhu, Dong; He, Xiang; Li, Guoping] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Chengdu Inst Resp Hlth, Lab Allergy & Precis Med,Affiliated Hosp, Chengdu, Peoples R China; [Zhu, Dong; He, Xiang; Li, Guoping] ChongQing Med Univ, Chengdu Peoples Hosp Branch 3, Dept Pulm & Crit Care Med, Natl Clin Res Ctr Resp Dis,Affiliated Hosp, Chengdu, Peoples R China"

通信作者："Li, GP; Chen, M (通讯作者)，Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China."

来源：SCIENCE PROGRESS

ESI学科分类：Multidisciplinary

WOS号：WOS:001192329200001

JCR分区：Q2

影响因子：2.1

年份：2024

卷号：107

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：HPV-positive; head and neck; squamous cell carcinoma; tumor microenvironment; immune therapy

摘要："Objectives Research progress of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) based on immune microenvironment.Methods This article preliminarily discusses the composition of immune microenvironment components and immune therapy and elaborates and analyzes the involvement and impact of T cells, B cells, natural killer (NK) cells, tumor-associated fibroblasts, and bone marrow-derived suppressor cells in HPV-positive HNSCC on tumor progression and prognosis. Furthermore, the application of immune-related therapies in HPV-positive HNSCC is explored.Results It is found that immune microenvironment research plays an important role in the pathogenesis and treatment of HPV-positive HNSCC.Conclusions Immune microenvironment research as an important means to explore tumors has played an important role in the study of HPV-positive HNSCC. We describe the biological significance of important components of HNSCC immune microenvironment by analyzing the effects of HNSCC immune microenvironment components and immunotherapy on HPV-positive HNSCC. May to provide new strategies for experimental research and clinical prevention and treatment of this disease."

基金机构："The Science and Technology Development Fund, Macau SAR"

基金资助正文：We are grateful for the funding support provided by Professor Chen Min.