A Review on The Pathogenesis of Cardiovascular Disease of <i>Flaviviridea</i> Viruses Infection

作者全名："Yang, Tie-Hua; Gao, Wen-Cong; Ma, Xin; Liu, Qian; Pang, Pan-Pan; Zheng, Yong-Tang; Jia, Yinnong; Zheng, Chang-Bo"

作者地址："[Yang, Tie-Hua; Pang, Pan-Pan] Yunnan Univ Chinese Med, Sch Chinese Mat Med, Kunming 650500, Peoples R China; [Yang, Tie-Hua; Ma, Xin; Pang, Pan-Pan; Zheng, Yong-Tang] Chinese Acad Sci, Kunming Inst Zool, Ctr Biosafety Mega Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650201, Peoples R China; [Yang, Tie-Hua; Zheng, Yong-Tang] Chinese Acad Sci, Kunming Inst Zool, Engn Lab Peptides,KIZ CUHK Joint Lab Bioresources, Ctr Biosafety Mega Sci,Key Lab Bioact Peptides Yun, Kunming 650223, Peoples R China; [Gao, Wen-Cong; Jia, Yinnong; Zheng, Chang-Bo] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China; [Gao, Wen-Cong; Jia, Yinnong; Zheng, Chang-Bo] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China; [Ma, Xin; Zheng, Chang-Bo] Kunming Med Univ, Coll Modern Biomed Ind, Kunming 650500, Peoples R China; [Liu, Qian] Chongqing Med Univ, Sch Pharm, Chongqing 400016, Peoples R China; [Zheng, Chang-Bo] Yunnan Vaccine Lab, Kunming 650500, Peoples R China"

通信作者："Jia, YN; Zheng, CB (通讯作者)，Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China.; Jia, YN; Zheng, CB (通讯作者)，Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China.; Zheng, CB (通讯作者)，Kunming Med Univ, Coll Modern Biomed Ind, Kunming 650500, Peoples R China.; Zheng, CB (通讯作者)，Yunnan Vaccine Lab, Kunming 650500, Peoples R China."

来源：VIRUSES-BASEL

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001193494200001

JCR分区：Q2

影响因子：3.8

年份：2024

卷号：16

期号：3

开始页：　

结束页：　

文献类型：Review

关键词：Flaviviridae viruses; Flavivirus; Hepacivirus; cardiovascular disease

摘要："Members of the Flaviviridae family, encompassing the Flavivirus and Hepacivirus genera, are implicated in a spectrum of severe human pathologies. These diseases span a diverse spectrum, including hepatitis, vascular shock syndrome, encephalitis, acute flaccid paralysis, and adverse fetal outcomes, such as congenital heart defects and increased mortality rates. Notably, infections by Flaviviridae viruses have been associated with substantial cardiovascular compromise, yet the exploration into the attendant cardiovascular sequelae and underlying mechanisms remains relatively underexplored. This review aims to explore the epidemiology of Flaviviridae virus infections and synthesize their cardiovascular morbidities. Leveraging current research trajectories and our investigative contributions, we aspire to construct a cogent theoretical framework elucidating the pathogenesis of Flaviviridae-induced cardiovascular injury and illuminate prospective therapeutic avenues."

基金机构：National Natural Science Foundation of China; National Natural Science Foundation of China and various organizations

基金资助正文：We would like to thank the National Natural Science Foundation of China and various organizations for financial support and all authors for their contributions to this review.