Identifying Predictors for Hypoplastic Aortic Arch (HAA) in Pediatric Patients with Complex Coarctation of the Aorta (CoA)

作者全名："Lyu, Ying; Tian, Lu; Qin, Bin; Fan, Xiao; He, Ling"

作者地址："[Lyu, Ying; Tian, Lu; Qin, Bin; Fan, Xiao; He, Ling] Chongqing Med Univ, Dept Radiol, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders,Minist Ed, Chongqing 400014, Peoples R China; [He, Ling] Chongqing Med Univ, Childrens Hosp, Dept Radiol, 136 Zhongshan Er Rd, Chongqing, Peoples R China"

通信作者："He, L (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Radiol, 136 Zhongshan Er Rd, Chongqing, Peoples R China."

来源：CURRENT MEDICAL IMAGING

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001194091500001

JCR分区：Q3

影响因子：1.1

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Children; Hypoplastic aortic arch; Coarctation of aorta; Aortic diseases; Congenital heart disease; Computed tomography

摘要："Objective HAA is a significant risk factor in complex CoA patients. We conducted a retrospective study to explore the relationship between HAA and other cardiovascular factors. Methods We analyzed 103 patients diagnosed with complex CoA using CT angiography and echocardiography. Aortic diameter was measured at six levels, and severe coarctation was defined as coarctation site to diaphragmatic level ratio (CDR) < 50%. Correlations between non-HAA and HAA groups were assessed. Univariate and multivariate logistic regression identified HAA risk factors. Results Among 103 children with complex CoA, 55 were in the non-HAA group and 48 in the HAA group. The incidence of PDA (56.3% vs. 32.7%, p < 0.05), severe coarctation (CDR < 50%, 81.3% vs. 34.5%, p < 0.01), and collateral arteries (39.6% vs. 0, p < 0.01) were higher in the HAA group than one in the non-HAA group. The aortic arch size was positively correlated with age and negatively correlated with severe coarctation, VSD, collateral arteries, and left heart dysfunction. Logistic regression results showed that collateral arteries were risk factors for the whole aortic arch (proximal arch OR = 11.458; p < 0.01, distal arch OR = 4.211; p < 0.05, and isthmus OR = 11.744; p < 0.01), severe coarctation (OR = 6.653; p < 0.01), and left heart dysfunction (OR = 5.149; p < 0.01) associated with isthmus hypoplasia. Conclusion This study highlights the prevalence of HAA in complex CoA patients and its associations with various cardiovascular factors. These insights improve diagnosis and treatment approaches."

基金机构："Basic Research and Frontier Exploration Project (Yuzhong District, Chongqing, China) [20200155]"

基金资助正文："The project was funded by Basic Research and Frontier Exploration Project (Yuzhong District, Chongqing, China) (Grant No.20200155)"