Mechanism study of ubiquitination in T cell development and autoimmune disease

作者全名："Yu, Hui; Yang, Wenyong; Cao, Min; Lei, Qingqiang; Yuan, Renbin; Xu, He; Cui, Yuqian; Chen, Xuerui; Su, Xu; Zhuo, Hui; Lin, Liangbin"

作者地址："[Yu, Hui; Yang, Wenyong; Cao, Min; Lei, Qingqiang; Yuan, Renbin; Xu, He; Cui, Yuqian; Chen, Xuerui; Su, Xu; Zhuo, Hui; Lin, Liangbin] Dept Urol Med Res Ctr Dept Neurosurg Affiliated Ho, Chongqing Med Univ, Southwest Jiaotong Univ, Chengdu Hosp 2,Dept Urol,Med Res Ctr,Dept Neurosur, Chengdu, Peoples R China; [Su, Xu] Southwest Jiaotong Univ, Coll Med, Chengdu, Peoples R China"

通信作者："Zhuo, H; Lin, LB (通讯作者)，Dept Urol Med Res Ctr Dept Neurosurg Affiliated Ho, Chongqing Med Univ, Southwest Jiaotong Univ, Chengdu Hosp 2,Dept Urol,Med Res Ctr,Dept Neurosur, Chengdu, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001194506300001

JCR分区：Q1

影响因子：5.7

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：ubiquitination; T cell development; self-tolerance; Treg; E3 ubiquitin ligase; TEC; autoimmune disease

摘要："T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in thymus and undergo T cell-lineage commitment, proliferation, T cell receptor (TCR) rearrangement, and thymic selections driven by microenvironment composed of thymic epithelial cells (TEC), dendritic cells (DC), macrophage and B cells, thus generating T cells with diverse TCR repertoire immunocompetent but not self-reactive. Additionally, some self-reactive thymocytes give rise to Treg with the help of TEC and DC, serving for immune tolerance. The sequential proliferation, cell fate decision, and selection during T cell development and self-tolerance establishment are tightly regulated to ensure the proper immune response without autoimmune reaction. There are remarkable progresses in understanding of the regulatory mechanisms regarding ubiquitination in T cell development and the establishment of self-tolerance in the past few years, which holds great potential for further therapeutic interventions in immune-related diseases."

基金机构：National Natural Science Foundation of China10.13039/501100001809

基金资助正文：No Statement Available