"PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment"

作者全名："Gao, Jie; Xiong, Anying; Liu, Jiliu; Li, Xiaolan; Wang, Junyi; Zhang, Lei; Liu, Yao; Xiong, Ying; Li, Guoping; He, Xiang"

作者地址："[Gao, Jie; Xiong, Anying; Liu, Jiliu; Li, Xiaolan; Wang, Junyi; Zhang, Lei; Liu, Yao; Li, Guoping; He, Xiang] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Chengdu Inst Resp Hlth, Lab Allergy & Precis Med,Affiliated Hosp, Chengdu 610031, Peoples R China; [Gao, Jie; Xiong, Anying; Liu, Jiliu; Li, Xiaolan; Wang, Junyi; Zhang, Lei; Liu, Yao; Li, Guoping; He, Xiang] ChongQing Med Univ, Chengdu Peoples Hosp Branch 3, Dept Pulm & Crit Care Med, Affiliated Hosp,Natl Clin Res Ctr Resp Dis, Chengdu 610031, Peoples R China; [Li, Xiaolan; He, Xiang] Med Univ Guangzhou, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis, Natl Ctr Resp Med,Inst Resp Hlth,Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China; [Xiong, Ying] Sichuan Friendship Hosp, Dept Pulm & Crit Care Med, Chengdu 610000, Peoples R China"

通信作者："Li, GP; He, X (通讯作者)，Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Chengdu Inst Resp Hlth, Lab Allergy & Precis Med,Affiliated Hosp, Chengdu 610031, Peoples R China.; Li, GP; He, X (通讯作者)，ChongQing Med Univ, Chengdu Peoples Hosp Branch 3, Dept Pulm & Crit Care Med, Affiliated Hosp,Natl Clin Res Ctr Resp Dis, Chengdu 610031, Peoples R China.; He, X (通讯作者)，Med Univ Guangzhou, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis, Natl Ctr Resp Med,Inst Resp Hlth,Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China."

来源：CANCER GENE THERAPY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001194605700002

JCR分区：Q1

影响因子：4.8

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：　

摘要："This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence of apoptosis, pyroptosis, and necroptosis, plays a crucial role in cell death and immune response regulation. The study delves into the molecular pathways of each cell death mechanism and their crosstalk within PANoptosis, emphasizing the shared components like caspases and the PANoptosome complex. It highlights the significant role of PANoptosis in various cancers, including respiratory, digestive, genitourinary, gliomas, and breast cancers, showing its impact on tumorigenesis and patient survival rates. We further discuss the interwoven relationship between PANoptosis and the tumor microenvironment (TME), illustrating how PANoptosis influences immune cell behavior and tumor progression. It underscores the dynamic interplay between tumors and their microenvironments, focusing on the roles of different immune cells and their interactions with cancer cells. Moreover, the review presents new breakthroughs in cancer therapy, emphasizing the potential of targeting PANoptosis to enhance anti-tumor immunity. It outlines various strategies to manipulate PANoptosis pathways for therapeutic purposes, such as targeting key signaling molecules like caspases, NLRP3, RIPK1, and RIPK3. The potential of novel treatments like immunogenic PANoptosis-initiated therapies and nanoparticle-based strategies is also explored."

基金机构："National Natural Science Foundation of China (National Science Foundation of China) [82370023, 82370022]; National Natural Science Foundation of China [2023M730799]; China Postdoctoral Science Foundation [ZX20201202020]; Chengdu High-level Key Clinical Specialty Construction Project [2021-YF09-00102-SN]; Chengdu Science and Technology Bureau [2021011, 2021040, 2022193]; Health Commission of Chengdu"

基金资助正文："This work was supported by the National Natural Science Foundation of China (82370023, 82370022), China Postdoctoral Science Foundation (2023M730799), Chengdu High-level Key Clinical Specialty Construction Project (ZX20201202020), Chengdu Science and Technology Bureau (2021-YF09-00102-SN), Health Commission of Chengdu (2021011, 2021040, 2022193)."