"The Impact of SARS-CoV-2 Infection on the Length of Stay in the Neuro-ICU:A Prospective Multicenter Cohort Study in Eight Neuro-ICU, China Between February and April 2023"

作者全名："Tan, Liang; Wang, Feilong; Huang, Yi; Fu, Chuhua; Zhang, Haijun; Feng, Jianfei; Xu, Yincai; Ye, Xinzhen; Tang, Rongrui; Chen, Yinglian; Mou, Liansheng; Li, Ronghao; Chen, Jingyu; Xian, Jishu"

作者地址："[Tan, Liang; Wang, Feilong; Mou, Liansheng; Li, Ronghao; Chen, Jingyu; Xian, Jishu] Army Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Huang, Yi] Ninth Peoples Hosp Chongqing, Dept Neurosurg, Chongqing, Peoples R China; [Fu, Chuhua] Univ Med, Xiangyang Peoples Hosp 1, Dept Neurosurg, Xiangyang, Hubei, Peoples R China; [Zhang, Haijun] Kaifeng Cent Hosp, Dept Neurosurg, Kaifeng, Henan, Peoples R China; [Feng, Jianfei] Beibei Tradit Chinese Med Hosp, Dept Encephalopathy, Chongqing, Peoples R China; [Xu, Yincai] Zheng Coal Gen Hosp, Dept Neurosurg, Zhengzhou, Henan, Peoples R China; [Ye, Xinzhen] Songshan Gen Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Tang, Rongrui] Chongqing Med Univ, Dept Neurosurg, Univ Town Hosp, Chongqing, Peoples R China; [Chen, Yinglian] Zhuhai Brainlightning Res Inst, Zhuhai, Guangdong, Peoples R China; [Mou, Liansheng] Liangping Dist Peoples Hosp, Dept Neurosurg, Chongqing, Peoples R China; [Li, Ronghao] Army Med Univ, Dept Basic Med, Chongqing, Peoples R China"

通信作者："Chen, JY; Xian, JS (通讯作者)，Army Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing, Peoples R China."

来源：NEUROPSYCHIATRIC DISEASE AND TREATMENT

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001194716400001

JCR分区：Q2

影响因子：2.5

年份：2024

卷号：20

期号：　

开始页：765

结束页：775

文献类型：Article

关键词：SARS-CoV-2; intensive care unit; intracerebral hemorrhage; subarachnoid hemorrhage; traumatic brain injury

摘要："Purpose: The SARS-CoV-2 infection cases are increasing rapidly in neuro-intensive care units (neuro-ICUs) at the beginning of 2023 in China. We aimed to characterize the prevalence, risk factors, and prognosis of critically ill patients treated in neuro-ICUs. Materials and Methods: In the prospective, multicenter, observational registry study, critically ill patients with intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and traumatic brain injury (TBI) admitted to eight Chinese neuro-ICUs between Feb 16, 2023, to Apr 30, 2023 were enrolled for the study. Mortality and ICU stay day were used as the primary outcomes. Results: 131 patients were finally included and analyzed (mean age 60.36 years [SD 13.81], 64.12% male, 39.69% SARS-CoV-2 infected). The mortality is higher in the SARS-CoV-2 infection group without statistical signification (7.69% vs 5.06%, p>0.05). The length of stay (LOS) in neuro-ICUs was significantly longer among the SARS-CoV-2 infection patients (7(1-12) vs 4(1-8), p<0.01), with increased viral pneumonia occurrence (58.54% vs 7.32%, p<0.01). SARS-CoV-2 infection, surgery, and low GCS scores were independent risk factors for prolonged LOS, and respiratory/renal failure were independent risk factors for death. Conclusion: Based on the present neuro-ICU cohort, SARS-CoV-2 infection was a significant risk for the prolonged LOS of neurocritically ill patients. Trial Registration: Registered with Chictr.org.cn (ChiCTR2300068355) at 16 February 2023, Prospective registration. https://www. chictr.org.cn/showproj.html?proj=188252."

基金机构：Chongqing Middle and Young Medical High -end Talent Project; Scientific Research Program of the Education Department of Hubei Province [D20222103]; Chongqing Science -health joint medical research project [2022QNXM27]

基金资助正文："This study was supported by the Chongqing Middle and Young Medical High -end Talent Project, the Scientific Research Program of the Education Department of Hubei Province (Grant number D20222103) , and the Chongqing Science -health joint medical research project (2022QNXM27). The funders were not involved in the study design, data collection/ interpretation, and the decision to submit the publication results."