Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus

作者全名："Zhao, Mingdan; Huang, Fujun; Tang, Lei; Zhou, Xun; Zhang, Miao; Liao, Mengxue; Liu, Lirong; Huang, Mengya"

作者地址："[Zhao, Mingdan; Tang, Lei; Zhou, Xun; Huang, Mengya] Chongqing Hosp Tradit Chinese Med, Dept Dermatol & Cosmetol, Chongqing, Peoples R China; [Huang, Fujun; Zhang, Miao; Liao, Mengxue; Liu, Lirong] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing, Peoples R China"

通信作者："Huang, MY (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Dermatol & Cosmetol, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001194919000001

JCR分区：Q1

影响因子：5.7

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：case report; treatment; acute generalized pustular psoriasis; oral; tacrolimus

摘要："Acute generalized pustular psoriasis (GPP) is a serious illness. Despite various treatment methods, there is still lack of effective treatment plans for refractory cases with multiple comorbidities. This case report presents a 67-year-old woman with acute GPP, stage 4 chronic kidney disease (CKD), type 2 diabetes, and cardiovascular disease, in whom skin symptom disappearance and kidney function improvement were observed after the use of oral tacrolimus as the sole therapy. This is the first report on the application of tacrolimus in the treatment of acute GPP, especially refractory acute GPP. The successful treatment indicates that there are shared immune pathways between acute GPP and CKD, and the pathways can be interdicted by tacrolimus. Further studies are needed to optimize the therapy to maximize efficacy and minimize toxicity."

基金机构：Chongqing Talent Plan Project of Chongqing Municipal Health Commission; Top Young Talent of Chongqing Hospital of Traditional Chinese Medicine

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by grants from the Chongqing Talent Plan Project of Chongqing Municipal Health Commission (Grant NO.CQYC20200303138) and the Top Young Talent of Chongqing Hospital of Traditional Chinese Medicine."