Construction of cyclobutane-fused tetracyclic skeletons <i>via</i> substrate-dependent EnT-enabled dearomative [2+2] cycloaddition of benzofurans (benzothiophenes)/maleimides
作者全名："Liao, Zhi-Yu; Gao, Fan; Ye, Yu-Hang; Yu, Qian-Hui; Yang, Cui; Luo, Qing-Yu; Du, Fei; Pan, Bin; Zhong, Wen-Wu; Liang, Wu"
作者地址："[Liao, Zhi-Yu; Gao, Fan; Ye, Yu-Hang; Yu, Qian-Hui; Yang, Cui; Luo, Qing-Yu; Du, Fei; Liang, Wu] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Zhong, Wen-Wu] Chongqing Med & Pharmaceut Coll, Dept Pharm, Chongqing 401334, Peoples R China; [Pan, Bin] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China"
通信作者："Liang, W (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China.; Zhong, WW (通讯作者)，Chongqing Med & Pharmaceut Coll, Dept Pharm, Chongqing 401334, Peoples R China."
来源：CHEMICAL COMMUNICATIONS
ESI学科分类：CHEMISTRY
WOS号：WOS:001195268000001
JCR分区：Q2
影响因子：4.3
年份：2024
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期号：
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文献类型：Article; Early Access
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摘要："Herein, a novel and facile organic photosensitizer (thioxanthone)-mediated energy-transfer-enabled (EnT-enabled) dearomative [2+2] cycloaddition of aromatic heterocycles/maleimides for green synthesis of cyclobutane-fused polycyclic skeletons is reported. Mechanistic investigations revealed that different EnT pathways by triplet thioxanthone were initiated when different aromatic heterocycles participated in the reaction, giving the corresponding excited intermediates, which underwent the subsequent intermolecular [2+2] cycloaddition to access the desired highly functionalized cyclobutane-fused polycyclic skeletons."
基金机构：Chongqing Municipal Education Commission [KJQN202100453]; College of Pharmacy CQMU [YXY2021XSZ03]; CQMU Program for Youth Innovationin Future Medicine [172020320220090 W0072]
基金资助正文："Financial support from Chongqing Municipal Education Commission (KJQN202100453), College of Pharmacy CQMU(YXY2021XSZ03), and the CQMU Program for Youth Innovationin Future Medicine (172020320220090 W0072) is gratefully acknowledged."
