Universal cell membrane camouflaged nano-prodrugs with right-side-out orientation adapting for positive pathological vascular remodeling in atherosclerosis

作者全名："Qin, Xian; Zhu, Li; Zhong, Yuan; Wang, Yi; Luo, Xiaoshan; Li, Jiawei; Yan, Fei; Wu, Guicheng; Qiu, Juhui; Wang, Guixue; Qu, Kai; Zhang, Kun; Wu, Wei"

作者地址："[Qin, Xian; Zhu, Li; Zhong, Yuan; Qiu, Juhui; Wang, Guixue; Qu, Kai; Zhang, Kun; Wu, Wei] Chongqing Univ, Bioengn Coll, State & Local Joint Engn Lab Vasc Implants, Key Lab Biorheol Sci & Technol,Minist Educ, Chongqing 400030, Peoples R China; [Qin, Xian; Li, Jiawei; Yan, Fei; Wu, Guicheng; Qu, Kai; Zhang, Kun] Chongqing Univ, Three Gorges Hosp, Chongqing Municipal Clin Res Ctr Geriatr Dis, Chongqing 404000, Peoples R China; [Qin, Xian; Li, Jiawei; Qu, Kai; Zhang, Kun] Chongqing Univ, Sch Med, Chongqing 404010, Peoples R China; [Wang, Guixue; Wu, Wei] Jinfeng Lab, Chongqing 401329, Peoples R China; [Wang, Yi] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Luo, Xiaoshan] Guizhou Informat Engn Univ, Bijie 551700, Peoples R China"

通信作者："Qu, K; Zhang, K; Wu, W (通讯作者)，Chongqing Univ, Bioengn Coll, State & Local Joint Engn Lab Vasc Implants, Key Lab Biorheol Sci & Technol,Minist Educ, Chongqing 400030, Peoples R China.; Qu, K; Zhang, K (通讯作者)，Chongqing Univ, Three Gorges Hosp, Chongqing Municipal Clin Res Ctr Geriatr Dis, Chongqing 404000, Peoples R China.; Qu, K; Zhang, K (通讯作者)，Chongqing Univ, Sch Med, Chongqing 404010, Peoples R China.; Wu, W (通讯作者)，Jinfeng Lab, Chongqing 401329, Peoples R China."

来源：CHEMICAL SCIENCE

ESI学科分类：CHEMISTRY

WOS号：WOS:001196938500001

JCR分区：Q1

影响因子：7.6

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：　

摘要："A right-side-out orientated self-assembly of cell membrane-camouflaged nanotherapeutics is crucial for ensuring their biological functionality inherited from the source cells. In this study, a universal and spontaneous right-side-out coupling-driven ROS-responsive nanotherapeutic approach, based on the intrinsic affinity between phosphatidylserine (PS) on the inner leaflet and PS-targeted peptide modified nanoparticles, has been developed to target foam cells in atherosclerotic plaques. Considering the increased osteopontin (OPN) secretion from foam cells in plaques, a bioengineered cell membrane (OEM) with an overexpression of integrin alpha 9 beta 1 is integrated with ROS-cleavable prodrugs, OEM-coated ETBNPs (OEM-ETBNPs), to enhance targeted drug delivery and on-demand drug release in the local lesion of atherosclerosis. Both in vitro and in vivo experimental results confirm that OEM-ETBNPs are able to inhibit cellular lipid uptake and simultaneously promote intracellular lipid efflux, regulating the positive cellular phenotypic conversion. This finding offers a versatile platform for the biomedical applications of universal cell membrane camouflaging biomimetic nanotechnology. The preparation of right-side-out-orientated coupling-driven ROS-sensitive nanoparticles on the inner leaflet of the cell membrane for positively regulating cell phenotypic conversion in atherosclerosis."

基金机构："Central University Basic Research Fund of China [2022YFF0710700]; National Key Research and Development Program of China [31971301, 32171324, 12102072, 52303146]; National Natural Science Foundation of China [cstc2021jcyj-msxmX0149, CSTB2022NSCQ-BHX0724, CSTB2022NSCQ-BHX0718, CSTB2023NSCQ-BHX0067]; Natural Science Foundation of Chongqing [jfkyjf202203001]; JinFeng Laboratory of Chongqing [2023CDJXY-051, 2022CDJXY-026, 2020CDJQY-A061, 2022CDJYGRH-011]; Fundamental Research Funds for Central Universities [wzstc20220314, wzstc20230408, wzstc20220410]; Chongqing Wanzhou District; Analysis and Testing Center of Chongqing University"

基金资助正文："This work was supported by grants from the National Key Research and Development Program of China (2022YFF0710700), National Natural Science Foundation of China (31971301, 32171324, 12102072, and 52303146), Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0149, CSTB2022NSCQ-BHX0724, CSTB2022NSCQ-BHX0718, and CSTB2023NSCQ-BHX0067), JinFeng Laboratory of Chongqing (jfkyjf202203001), Fundamental Research Funds for Central Universities (2023CDJXY-051, 2022CDJXY-026, 2020CDJQY-A061, and 2022CDJYGRH-011), Chongqing Wanzhou District PhD Direct-Access Research Project (wzstc20220314, wzstc20230408, and wzstc20220410). In addition, some large instruments and equipment were provided by the Analysis and Testing Center of Chongqing University."