"The Exosome-Mediated Bone Regeneration: An Advanced Horizon Toward the Isolation, Engineering, Carrying Modalities, and Mechanisms"

作者全名："Zhu, Fukang; Wang, Taiyou; Wang, Guangjian; Yan, Caiping; He, Bin; Qiao, Bo"

作者地址："[Zhu, Fukang; Wang, Taiyou; Wang, Guangjian; He, Bin; Qiao, Bo] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed, 1 Youyi Rd, Chongqing 400010, Peoples R China; [Zhu, Fukang; Wang, Taiyou; He, Bin; Qiao, Bo] Chongqing Med Univ, Orthoped Lab, Affiliated Hosp 1, Chongqing 400010, Peoples R China; [Wang, Guangjian] Peoples Hosp Rongchang Dist, Dept Orthopaed, Chongqing 402460, Peoples R China; [Yan, Caiping] Chongqing Med Univ, Affiliated Hosp 3, Dept Orthopaed, Chongqing 401120, Peoples R China"

通信作者："Qiao, B (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed, 1 Youyi Rd, Chongqing 400010, Peoples R China.; Qiao, B (通讯作者)，Chongqing Med Univ, Orthoped Lab, Affiliated Hosp 1, Chongqing 400010, Peoples R China."

来源：ADVANCED HEALTHCARE MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001196945000001

JCR分区：Q1

影响因子：10

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：angiogenesis; bone regeneration; carry modality; exosome; exosome isolation; exosome engineering; nerve regeneration

摘要："Exosomes, nanoparticles secreted by various cells, composed of a bilayer lipid membrane, and containing bioactive substances such as proteins, nucleic acids, metabolites, etc., have been intensively investigated in tissue engineering owing to their high biocompatibility and versatile biofunction. However, there is still a lack of a high-quality review on bone defect regeneration potentiated by exosomes. In this review, the biogenesis and isolation methods of exosomes are first introduced. More importantly, the engineered exosomes of the current state of knowledge are discussed intensively in this review. Afterward, the biomaterial carriers of exosomes and the mechanisms of bone repair elucidated by compelling evidence are presented. Thus, future perspectives and concerns are revealed to help devise advanced modalities based on exosomes to overcome the challenges of bone regeneration. It is totally believed this review will attract special attention from clinicians and provide promising ideas for their future works. Exosomes hold promise for tissue engineering. However, challenges in exosome-based osteogenesis persist, including optimal segregation workflows to achieve industrial production, safety decoration formulations to exert better biofunctions, loading modalities to prevent rapid dissipation, and an understanding of their regulated mechanisms. This review offers an advanced view of these crucial aspects, guiding future research directions. image"

基金机构：National Natural Science Foundation of China; [82072449]

基金资助正文：F.Z. and T.W. contributed equally to this work. The authors would like to thank the fund support from the National Natural Science Foundation of China (Grant No. 82072449). F.Z. wrote the original manuscript and B.Q. provided the research ideas. All authors had read and approved the submission of the manuscript. All of the figures were created with BioRender.com.