"Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Does Not Improve Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, SingleBlinded, Randomized Study"

作者全名："Lei, Mingjie; Zhu, Zhenglin; Hu, Xiaobo; Wu, Dandong; Huang, Wei; Zhang, Yong; Chen, Hong"

作者地址："[Lei, Mingjie; Zhu, Zhenglin; Huang, Wei; Chen, Hong] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China; [Lei, Mingjie; Zhu, Zhenglin; Huang, Wei; Chen, Hong] Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China; [Hu, Xiaobo] Chongqing Tradit Chinese Med Hosp, Dept Orthoped, Chongqing, Peoples R China; [Wu, Dandong] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil, Chongqing, Peoples R China; [Zhang, Yong] Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, Chongqing, Peoples R China; [Chen, Hong] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Chen, H (通讯作者)，Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001197386300001

JCR分区：Q1

影响因子：4.4

年份：2024

卷号：40

期号：3

开始页：714

结束页：722

文献类型：Article

关键词：　

摘要："Purpose: To investigate the effect of the antiosteoporotic agent zoledronic acid (ZA) on rotator cuff healing and clinical outcomes in patients with postmenopausal osteoporosis. Methods: We prospectively enrolled 138 female patients with postmenopausal osteoporosis who were scheduled to undergo arthroscopic rotator cuff repair (ARCR) from March 2020 to March 2021. Patients were randomly allocated to the ZA group (ARCR followed by intravenous ZA infusions at postoperative Day 1 and 1 year later) and the control group (ARCR alone). All patients were followed up for 24 months. Tendon healing was evaluated by ultrasonography at 6 weeks and 24 months after surgery. The American Shoulder and Elbow Surgeons (ASES) score, Western Ontario Rotator Cuff (WORC) index, and Numeric Rating Scale (NRS) for pain were recorded at each follow-up, and the minimal clinically important difference (MCID) was calculated. Results: A total of 124 patients were included in the final analysis, 61 in the ZA group and 63 in the control group. There was no statistically significant difference in participant characteristics between the 2 groups. The ZA group had a significantly higher tendon healing rate than the control group at 2 years after surgery (odds ratio = 5.0; 95% confidence interval [CI], 1.4-18.7; P = .014). Regarding clinical outcomes, 100% of patients exceeded the MCID in both groups, and no significant differences were found at 2 years after surgery between the 2 groups (ASES: 2.5 [95% CI, -2.2 to 7.2; P = .291]; WORC index: 4.5 [95% CI, -0.117 to 9.117; P = .056]; NRS: -0.1 [95% CI, -0.3 to 0.1; P = .394]). Conclusions: Antiosteoporotic treatment with ZA reduced the retear rate but did not significantly influence the clinical outcomes after ARCR in female patients with postmenopausal osteoporosis. Outcomes of ARCR showed good results in both groups and exceeded the MCID. Level of Evidence: Level I, randomized controlled trial."

基金机构：Chongqing medical sci-entific research project [2023MSXM142]; Chongqing Natural Science Foundation [cstc2019jcyjmsxmX0831]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202000430]

基金资助正文："The authors report the following potential conflicts of interest or sources of funding: This work was supported by grants from Chongqing medical sci-entific research project (No. 2023MSXM142) , Chongqing Natural Science Foundation (No. cstc2019jcyjmsxmX0831) , and the Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJQN202000430) . Full ICMJE author disclosure forms are available for this article online, as material."