Maternal Diabetes and Risk of Hypospadias: A Systemic Review and Meta-Analysis

作者全名："Liu, Zhiyuan; Yu, Chengjun; Yang, Shuhan; Luo, Jin; Zhang, Jie; Wang, Xiao; Wei, Chun; Shi, Qinlin; Hua, Yi; Liu, Xing; Wei, Guanghui"

作者地址："[Liu, Zhiyuan; Yu, Chengjun; Yang, Shuhan; Luo, Jin; Wang, Xiao; Wei, Chun; Shi, Qinlin; Hua, Yi; Liu, Xing; Wei, Guanghui] Chongqing Med Univ, Childrens Hosp, Dept Urol, Chongqing, Peoples R China; [Liu, Zhiyuan; Yu, Chengjun; Yang, Shuhan; Luo, Jin; Zhang, Jie; Wang, Xiao; Wei, Chun; Shi, Qinlin; Hua, Yi; Liu, Xing; Wei, Guanghui] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Yu, Chengjun; Luo, Jin; Zhang, Jie; Wei, Chun; Shi, Qinlin; Hua, Yi; Liu, Xing; Wei, Guanghui] Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing, Peoples R China; [Yu, Chengjun; Hua, Yi; Liu, Xing; Wei, Guanghui] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Yu, Chengjun; Luo, Jin; Zhang, Jie; Wei, Chun; Shi, Qinlin; Hua, Yi; Liu, Xing; Wei, Guanghui] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Yu, Chengjun; Luo, Jin; Zhang, Jie; Hua, Yi; Liu, Xing; Wei, Guanghui] Chongqing Key Lab Pediat Chongqing, Chongqing, Peoples R China"

通信作者："Wei, GH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Urol, Chongqing, Peoples R China.; Wei, GH (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.; Wei, GH (通讯作者)，Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing, Peoples R China.; Wei, GH (通讯作者)，Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Wei, GH (通讯作者)，China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.; Wei, GH (通讯作者)，Chongqing Key Lab Pediat Chongqing, Chongqing, Peoples R China."

来源：UROLOGIA INTERNATIONALIS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001197888200006

JCR分区：Q3

影响因子：1.5

年份：2024

卷号：108

期号：2

开始页：108

结束页：117

文献类型：Article

关键词：Hypospadias; Maternal diabetes; Pregestational diabetes mellitus; Gestational diabetes mellitus; Meta-analysis

摘要："Introduction: This study aimed to investigate the association between maternal diabetes and the risk of hypospadias in male infants, as the relationship between them remains uncertain. Methods: To comprehensively evaluate the association between pregestational diabetes mellitus and gestational diabetes mellitus with hypospadias, we conducted a systematic review and meta-analysis. A thorough literature search was conducted, encompassing relevant publications published prior to January 2023. Crude odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model. Results: Our meta-analysis comprised a total of 13 studies, 11 of which investigated the relationship between pregestational diabetes mellitus and hypospadias, while 9 studies explored the association between gestational diabetes mellitus and hypospadias. Notably, these investigations yielded compelling evidence of significant positive associations between pregestational diabetes mellitus and hypospadias (OR = 1.51, 95% CI = 1.13-2.03), as well as between gestational diabetes mellitus and hypospadias (OR = 1.18, 95% CI = 1.04-1.35). Conclusion: Our findings suggest that both pregestational diabetes mellitus and gestational diabetes mellitus are associated with an increased risk of hypospadias in offspring. Further investigations are needed to explore the optimal range of blood glucose during pregnancy that minimizes the risk of congenital malformation in the fetus, as well as to develop more effective measures for glycemic control in pregnant women."

基金机构：Joint Medical Research Project of Chongqing Science and Technology Bureau and Health Commission [2022ZDXM033]

基金资助正文：No Statement Available