"An integrative pan-cancer bioinformatics analysis of MSRB1 and its association with tumor immune microenvironment, prognosis, and immunotherapy"

作者全名："Jiang, Shanshan; Yang, Shengyong; Gao, Zhengdan; Yin, Chuan; Zhang, Mengmeng; Wu, Qian; Li, Yi"

作者地址："[Jiang, Shanshan; Yang, Shengyong; Gao, Zhengdan; Yin, Chuan; Zhang, Mengmeng; Li, Yi] Chongqing Med Univ, Coll Basic Med, Mol Med & Canc Res Ctr, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China; [Wu, Qian] Chongqing Tradit Chinese Med Hosp, Out Patient Dept, Chongqing 400011, Peoples R China"

通信作者："Li, Y (通讯作者)，Chongqing Med Univ, Coll Basic Med, Mol Med & Canc Res Ctr, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001198314000001

JCR分区：Q1

影响因子：3.4

年份：2024

卷号：10

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：MSRB1; Pan -cancer; Tumor microenvironment; Immunotherapy response; Biomarker

摘要："Methionine sulfoxide reductase B1 (MSRB1) is involved in the development and immune regulation of multiple tumors. However, the role of MSRB1 in the tumor microenvironment and its potential as a therapeutic target remain largely unknown. In this study, MSRB1 expression patterns were evaluated using pan-cancer RNA sequencing data from multiple cell lines, tissues, and single cells. The pan-cancer prognostic role of MSRB1 was assessed and the association between MSRB1 expression and certain cancer characteristics was analyzed. We showed that MSRB1 expression levels were increased in several types of cancer (P < 0.05) and in certain cell types (macrophages, dendritic cells, and malignant tumor cells). The upregulation of MSRB1 expression was due to DNA copy number amplification. Furthermore, MSRB1 was significantly associated with the activation of immune pathways (P < 0.05, NES > 0), immune cell infiltration, and expression of immune checkpoint molecules. In addition, high expression of MSRB1 was found in a series of in vivo and in vitro immunotherapy response models (P < 0.05), and showed resistance to most targeted drugs. Our results indicated that MSRB1 may regulate the tumor immune microenvironment through an immunoresponse and potentially influence cancer development. This could make it a promising predictive biomarker and therapeutic target for precise tumor immunotherapy."

基金机构："National Natural Science Foundation of China [81872444, 81602159]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0238, cstc2016jcyjA0054]; Science and Technology Planning Project of Yuzhong District, Chongqing City [20170109]"

基金资助正文："This research was supported by the National Natural Science Foundation of China grants 81872444 (S.-Y.Y.) and 81602159 (Y.L.) , the Natural Science Foundation of Chongqing grants cstc2021jcyj-msxmX0238 (S.-Y.Y.) and cstc2016jcyjA0054 (Y.L.) and the Science and Technology Planning Project of Yuzhong District, Chongqing City, grant 20170109 (S.-Y.Y.) ."