Hyperuricemia is associated with heart failure readmission in patients with heart failure and preserved ejection fraction-an observational study in Chinese

作者全名："Liu, Xiaohan; Huang, Gang; You, Yueting; Zhang, Yue; Wang, Tianbo; Zhu, Yuxin; He, Yun; Li, Jingting; Zhang, Zhen; Xu, Junbo"

作者地址："[Liu, Xiaohan; You, Yueting; Zhang, Yue; Wang, Tianbo; Zhu, Yuxin; Li, Jingting] Southwest Jiaotong Univ, Coll Med, Chengdu 610031, Sichuan, Peoples R China; [Liu, Xiaohan; Huang, Gang; Zhang, Yue; Wang, Tianbo; Zhu, Yuxin; He, Yun; Li, Jingting; Zhang, Zhen; Xu, Junbo] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Dept Anorectal, Affiliated Hosp, Chengdu 610031, Sichuan, Peoples R China; [Liu, Xiaohan; Huang, Gang; Zhang, Yue; Wang, Tianbo; Zhu, Yuxin; He, Yun; Li, Jingting; Zhang, Zhen; Xu, Junbo] Third Peoples Hosp Chengdu, Dept Cardiol, Chengdu 610031, Sichuan, Peoples R China; [Huang, Gang; He, Yun; Zhang, Zhen; Xu, Junbo] Cardiovasc Dis Res Inst Chengdu, Chengdu 610031, Sichuan, Peoples R China; [Huang, Gang; He, Yun; Zhang, Zhen; Xu, Junbo] Chongqing Med Univ, Affiliated Chengdu Clin Coll 2, Chengdu 610031, Sichuan, Peoples R China; [Huang, Gang; Xu, Junbo] Third Peoples Hosp Chengdu, Cardiovasc Dis Res Inst Chengdu, Dept Cardiol, 82 Qinglong St, Chengdu 610031, Sichuan, Peoples R China"

通信作者："Huang, G; Xu, JB (通讯作者)，Third Peoples Hosp Chengdu, Cardiovasc Dis Res Inst Chengdu, Dept Cardiol, 82 Qinglong St, Chengdu 610031, Sichuan, Peoples R China."

来源：NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001198351800001

JCR分区：Q2

影响因子：3.3

年份：2024

卷号：34

期号：2

开始页：521

结束页：528

文献类型：Article

关键词：Hyperuricemia; Heart failure; Preserved ejection

摘要："Background and aims: This study aimed to explore the association between hyperuricemia and heart failure (HF) readmission in HF patients with preserved ejection fraction (HFpEF) because the impact of hyperuricemia on the prognosis of these patients has not been fully understood. Methods and results: This retrospective observational study included 538 hospitalized patients diagnosed with HFpEF. A total of 57.6 % of patients with HFpEF suffered from hyperuricemia (serum uric acid (SUA) was >7 mg/dL in men and >6 mg/dL in women). Compared to those without hyperuricemia, patients with hyperuricemia were more likely to be female (62.6 % vs. 53.9 %, p = 0.044) and older (78.0 +/- 8.4 vs. 75.9 +/- 9.0 years, p = 0.008). Our Cox analysis revealed that SUA level (hazard ratio (HR) = 1.158, 95 % confidence interval (CI): 1.087-1.234, p<0.001) and hyperuricemia (HR = 1.846, 95 % CI: 1.308-2.606, p<0.001) were associated with HF readmission in patients with HFpEF, respectively. Kaplan-Meier analysis showed that patients with hyperuricemia had a significantly worse prognosis (p<0.001). The receiver operating characteristic analysis revealed that the area under the ROC curve of SUA for predicting HF readmission was 0.6276 (95 % CI: 0.5763-0.6790) and a designated cut-off value of 7.53 mg/dL. Conclusions: Hyperuricemia is a common comorbidity among patients with HFpEF. Moreover, SUA level and hyperuricemia have been shown to be associated with HF readmission. Therefore, it is meaningful to monitor SUA levels in patients with HFpEF during the whole treatment period of HF. Whereas, whether intervention of hyperuricemia could benefit patients with HFpEF needs further studies."

基金机构："Sichuan Health Commission [23LCYJ044]; Department of Human Resources and Social Security of Sichuan Province [2021-11]; Chengdu Municipal Health Commission [2021200, 2022392]; Science and Technology Bureau of Chengdu [2019-YF05-00523-SN]"

基金资助正文："<B>Funding</B> This study was supported by Sichuan Health Commission (Contracts No.: 23LCYJ044) , the Department of Human Resources and Social Security of Sichuan Province (Con-tracts No.: 2021-11) , the Chengdu Municipal Health Commission (Contracts Nos.: 2021200, 2022392) , and the Science and Technology Bureau of Chengdu (Contracts No.: 2019-YF05-00523-SN) ."