Visceral adipose tissue and risk of diabetic nephropathy: A Mendelian randomization study

作者全名："Tao, Min; Zhou, Guanghong; Liu, Jing; He, Miao; Luo, Xie; Wang, Cong; Zhang, Lili"

作者地址："[Tao, Min; Zhou, Guanghong; Liu, Jing; He, Miao; Luo, Xie; Wang, Cong; Zhang, Lili] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China; [Tao, Min] Kunming Med Univ, Affiliated Hosp 2, Med Dept, Kunming 650101, Yunnan, Peoples R China"

通信作者："Wang, C; Zhang, LL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China."

来源：DIABETES RESEARCH AND CLINICAL PRACTICE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001198407900001

JCR分区：Q1

影响因子：6.1

年份：2024

卷号：209

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Visceral adipose tissue; Diabetic Nephropathy; Mendelian randomization; Causal effect

摘要："Objective: Previous observational studies have established a correlation between visceral adipose tissue (VAT) and diabetic nephropathy (DN). However, the causality of this association remains unclear. Therefore, the aim of this study was to investigate the causal association between VAT and DN by employing two-sample Mendelian randomization (MR) methods. Methods: The primary MR approach employed was the random-effects inverse-variance weighted (IVW) method. Additionally, we employed alternative methods, including the weighted median (WM) approach, MR-Egger regression, and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO). Sensitivity analyses were conducted to evaluate the robustness of the MR analyses. Results: Genetically predicted higher VAT mass was causally associated with a higher risk of DN. The results of the MR analyses were as follows: IVW(Beta = 0.948, odds ratio (OR) = 2.581, 95 % confidence interval (CI) = 2.100-3.173, p = 1.980e-19), WM (Beta = 1.126, OR = 3.082, 95 % CI = 2.278-4.171, p = 2.997e-13), MR-Egger (Beta = 1.315, OR = 3.724, 95 % CI = 1.981-6.998, p = 6.446e-05), and MR-PRESSO (Beta = 0.914, OR = 2.493, 95 % CI = 2.292-2.695, p = 3.121e-16). No pleiotropy was detected (p = 0.230). Conclusions: This study provided genetic evidence that higher VAT mass was causally associated with a higher risk of DN."

基金机构："National Natural Science Foun-dation of China [81300702]; Natural Science Foundation Project of Chongqing CSTC [cstc2018jcyjAXO210, CSTB2022NSCQMSX1008]"

基金资助正文："<B>Funding</B> This research was supported by the National Natural Science Foun-dation of China (Grants 81300702 to L.L.Z.) , the Natural Science Foundation Project of Chongqing CSTC (cstc2018jcyjAXO210 to L.L.Z. and CSTB2022NSCQMSX1008 to C.W.) ."