Alterations of the gut microbiota in patients with schizophrenia

作者全名："Li, Zhuocan; Tao, Xiangkun; Wang, Dongfang; Pu, Juncai; Liu, Yiyun; Gui, Siwen; Zhong, Xiaogang; Yang, Dan; Zhou, Haipeng; Tao, Wei; Chen, Weiyi; Chen, Xiaopeng; Chen, Yue; Chen, Xiang; Xie, Peng"

作者地址："[Li, Zhuocan; Tao, Xiangkun; Wang, Dongfang; Pu, Juncai; Liu, Yiyun; Gui, Siwen; Zhong, Xiaogang; Yang, Dan; Zhou, Haipeng; Tao, Wei; Chen, Weiyi; Chen, Xiaopeng; Chen, Yue; Chen, Xiang; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Natl Hlth Commiss, Chongqing, Peoples R China; [Wang, Dongfang; Pu, Juncai; Liu, Yiyun; Gui, Siwen; Zhong, Xiaogang; Xie, Peng] Jinfeng Lab, Chongqing, Peoples R China; [Wang, Dongfang; Liu, Yiyun; Gui, Siwen; Xie, Peng] Chongqing Inst Brain & Intelligence, Chongqing, Peoples R China; [Pu, Juncai; Chen, Weiyi; Chen, Xiaopeng; Chen, Yue; Chen, Xiang; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Zhong, Xiaogang] Chongqing Med Univ, Coll Basic Med, Chongqing, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Natl Hlth Commiss, Chongqing, Peoples R China.; Xie, P (通讯作者)，Jinfeng Lab, Chongqing, Peoples R China.; Xie, P (通讯作者)，Chongqing Inst Brain & Intelligence, Chongqing, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001198582500001

JCR分区：Q2

影响因子：3.2

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：schizophrenia; gut microbiota; microbial biomarkers; microbial diversity; gut-brain-axis

摘要："Introduction Schizophrenia is a complex psychiatric disorder, of which molecular pathogenesis remains largely unknown. Accumulating evidence suggest that gut microbiota may affect brain function via the complex gut-brain axis, which may be a potential contributor to schizophrenia. However, the alteration of gut microbiota showed high heterogeneity across different studies. Therefore, this study aims to identify the consistently altered gut microbial taxa associated with schizophrenia.Methods We conducted a systematic search and synthesis of the up-to-date human gut microbiome studies on schizophrenia, and performed vote counting analyses to identify consistently changed microbiota. Further, we investigated the effects of potential confounders on the alteration of gut microbiota.Results We obtained 30 available clinical studies, and found that there was no strong evidence to support significant differences in alpha-diversity and beta-diversity between schizophrenic patients and healthy controls. Among 428 differential gut microbial taxa collected from original studies, we found that 8 gut microbial taxa were consistently up-regulated in schizophrenic patients, including Proteobacteria, Gammaproteobacteria, Lactobacillaceae, Enterobacteriaceae, Lactobacillus, Succinivibrio, Prevotella and Acidaminococcus. While 5 taxa were consistently down-regulated in schizophrenia, including Fusicatenibacter, Faecalibacterium, Roseburia, Coprococcus and Anaerostipes.Discussion These findings suggested that gut microbial changes in patients with schizophrenia were characterized by the depletion of anti-inflammatory butyrate-producing genera, and the enrichment of certain opportunistic bacteria genera and probiotics. This study contributes to further understanding the role of gut microbiota in schizophrenia, and developing microbiota-based diagnosis and therapy for schizophrenia."

基金机构："Joint Project of Chongqing Municipal Science and Technology Bureau and Chongqing Health Commission [2023CCXM003]; Natural Science Foundation Project of China [81820108015, 82101596, 82371526]; National Key Research and Development Program of China [2017YFA0505700]; Postdoctoral Research Foundation of China [2022MD723742, 2022MD723735]; Natural Science Foundation Project of Chongqing [cstc2022ycjh-bgzxm0033]; Young Elite Scientists Sponsorship Program by CAST [2021QNRC001]; Chongqing Postdoctoral Science Foundation [2022NSCQ-BHX1283]"

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was funded by the Joint Project of Chongqing Municipal Science and Technology Bureau and Chongqing Health Commission (2023CCXM003), the Natural Science Foundation Project of China (81820108015, 82101596, 82371526), the National Key Research and Development Program of China (2017YFA0505700), the Postdoctoral Research Foundation of China (2022MD723742, 2022MD723735), the Natural Science Foundation Project of Chongqing (cstc2022ycjh-bgzxm0033), Young Elite Scientists Sponsorship Program by CAST (2021QNRC001), and the Chongqing Postdoctoral Science Foundation (2022NSCQ-BHX1283)."