Effect of epidural dexmedetomidine in single-dose combined with ropivacaine for cesarean section

作者全名："Liu, Minghao; Chen, Xuezi; Guo, Dan"

作者地址："[Liu, Minghao; Guo, Dan] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Affiliated Peoples Hosp 5, Geriatr Dis Inst,Dept Anesthesiol,Clin Med Coll 2,, Chengdu, Peoples R China; [Chen, Xuezi] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China; [Guo, Dan] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Affiliated Peoples Hosp 5, Clin Med Coll 2,Dept Ultrasound Imaging,Geriatr Di, Chengdu 611137, Peoples R China"

通信作者："Guo, D (通讯作者)，Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Affiliated Peoples Hosp 5, Geriatr Dis Inst,Dept Anesthesiol,Clin Med Coll 2,, Chengdu, Peoples R China.; Guo, D (通讯作者)，Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Affiliated Peoples Hosp 5, Clin Med Coll 2,Dept Ultrasound Imaging,Geriatr Di, Chengdu 611137, Peoples R China."

来源：BMC ANESTHESIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001198690900001

JCR分区：Q2

影响因子：2.3

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Cesarean section; Dexmedetomidine; Epidural anesthesia; Pain; Sedation

摘要："Background Dexmedetomidine has arousal sedation and analgesic effects. We hypothesize that epidural dexmedetomidine in single-dose combined with ropivacaine improves the experience of parturient undergoing cesarean section under epidural anesthesia. This study is to investigate the effect of 0.5 mu g/kg epidural dexmedetomidine combined with epidural anesthesia (EA) in parturients undergoing cesarean section. Methods A total of 92 parturients were randomly divided into Group R (receiveing epidural ropivacaine alone) Group RD (receiveing epidural ropivacaine with 0.5 mu g/kg dexmedetomidine). The primary outcome and second outcome will be intraoperative NRS pain scores and Ramsay Sedation Scale. Results All 92 parturients were included in the analysis. The NRS were significantly lower in Group RD compared to Group R at all observation timepoint (P > 0.05). Higher Ramsay Sedation Scale was found in Group RD compared to Group R (P < 0.001). No parturient has experienced sedation score of 4 and above. No significant difference regarding the incidence of hypotension, bradycardia and nausea or vomiting, Apgar scores and the overall satisfaction with anesthesia was found between Group R and Group RD (P > 0.05). Conclusion Epidural dexmedetomidine of 0.5 mu g/kg added slightly extra analgesic effect to ropivacaine in EA for cesarean section. The sedation of 0.5 mu g/kg epidural dexmedetomidine did not cause mother-baby bonding deficit. Satisfaction with anesthesia wasn't significantly improved by epidural dexmedetomidine of 0.5 mu g/kg. No additional side effect allows larger dose of epidural dexmedetomidine attempt."

基金机构："Funding Chongqing Science and Technology Bureau [cstc2018jscx-msybx002]; Chongqing Health Bureau [2018GDRC009, 2018 jstg011, 2019jstg003, 2021jstg045]"

基金资助正文："This work was supported by Funding Chongqing Science and Technology Bureau (cstc2018jscx-msybx002) and Chongqing Health Bureau (2018GDRC009, 2018 jstg011, 2019jstg003, 2021jstg045)."