Sunflower pollen-derived microcapsules adsorb light and bacteria for enhanced antimicrobial photothermal therapy

作者全名："Yang, Yao; Wang, Bin; Liu, Qian; Wei, Zhenghua; Mou, Ziye; Li, Quan; Chen, Chunfa; You, Zaichun; Li, Bang Lin; Wang, Guansong; Xu, Zhi; Qian, Hang"

作者地址："[Yang, Yao; Wang, Bin; Wei, Zhenghua; Li, Quan; Chen, Chunfa; Wang, Guansong; Xu, Zhi; Qian, Hang] Third Mil Med Univ, Xinqiao Hosp, Inst Resp Dis, 183 Xinqiao St, Chongqing 400037, Peoples R China; [Wang, Bin; Wei, Zhenghua; Chen, Chunfa; Wang, Guansong; Xu, Zhi; Qian, Hang] Chongqing Key Lab Precis Med & Prevent Major Resp, Chongqing 400037, Peoples R China; [Liu, Qian] Chongqing Med Univ, Lab Teaching & Management Ctr, Lab Pharm & Chem, Chongqing 400016, Peoples R China; [Liu, Qian] Chongqing Med Univ, Lab Teaching & Management Ctr, Lab Tissue & Cell Biol, Chongqing 400016, Peoples R China; [Mou, Ziye; Li, Quan; You, Zaichun] Third Mil Med Univ, Xinqiao Hosp, Dept Gen Practice, Chongqing 400037, Peoples R China; [Li, Bang Lin] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China; [Xu, Zhi; Qian, Hang] Yu Yue Pathol Sci Res Ctr, Chongqing, Peoples R China"

通信作者："Wang, GS; Xu, Z; Qian, H (通讯作者)，Third Mil Med Univ, Xinqiao Hosp, Inst Resp Dis, 183 Xinqiao St, Chongqing 400037, Peoples R China.; Wang, GS; Xu, Z; Qian, H (通讯作者)，Chongqing Key Lab Precis Med & Prevent Major Resp, Chongqing 400037, Peoples R China.; Xu, Z; Qian, H (通讯作者)，Yu Yue Pathol Sci Res Ctr, Chongqing, Peoples R China."

来源：NANOSCALE

ESI学科分类：PHYSICS

WOS号：WOS:001199701200001

JCR分区：Q1

影响因子：5.8

年份：2024

卷号：　

期号：　

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文献类型：Article; Early Access

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摘要："Bacterial infection is one of the most serious clinical complications, with life-threatening outcomes. Nature-inspired biomaterials offer appealing microscale and nanoscale architectures that are often hard to fabricate by traditional technologies. Inspired by the light-harvesting nature, we engineered sulfuric acid-treated sunflower sporopollenin exine-derived microcapsules (HSECs) to capture light and bacteria for antimicrobial photothermal therapy. Sulfuric acid-treated HSECs show a greatly enhanced photothermal performance and a strong bacteria-capturing ability against Gram-positive bacteria. This is attributed to the hierarchical micro/nanostructure and surface chemistry alteration of HSECs. To test the potential for clinical application, an in situ bacteria-capturing, near-infrared (NIR) light-triggered hydrogel made of HSECs and curdlan is applied in photothermal therapy for infected skin wounds. HSECs and curdlan suspension that spread on bacteria-infected skin wounds of mice first capture the local bacteria and then form hydrogels on the wound upon NIR light stimulation. The combination shows a superior antibacterial efficiency of 98.4% compared to NIR therapy alone and achieved a wound healing ratio of 89.4%. The current study suggests that the bacteria-capturing ability and photothermal properties make HSECs an excellent platform for the phototherapy of bacteria-infected diseases. Future work that can fully take advantage of the hierarchical micro/nanostructure of HSECs for multiple biomedical applications is highly promising and desirable. In this study, we report that natural sunflower sporopollenin-based microcapsules (HSECs) and curdlan suspension capture bacteria locally and form hydrogels on wounds upon NIR light stimulation, showing superior wound healing results in both in vitro and in vivo."

基金机构："National Natural Science Foundation of China [82070071]; National Natural Science Foundation of China [2022YQB024]; Young PhD Incubation Program of Xinqiao Hospital, Army Medical University [2020FYYX179]; Chongqing Science and Health Joint Project [2019R025]; Key Support Object Training Project of Army Medical University"

基金资助正文："This research was supported by the National Natural Science Foundation of China (82070071); the Young PhD Incubation Program of Xinqiao Hospital, Army Medical University (2022YQB024); the Chongqing Science and Health Joint Project (2020FYYX179); and the Key Support Object Training Project of Army Medical University (No. 2019R025). We thank Ms Haolin Zou from Southwest University and Dr Haifeng Su from Xiamen University for their help in the materials' characterization. Yao Yang and Bin Wang contributed equally to this work."