Serum apelin as a potential biomarker for infantile hemangiomas
作者全名："Chen, Qiang; Zhang, Yunxuan; Ni, Sili; Yang, Liuqing; Li, Jiwei; Yuan, Xingang; Chen, Meng; Liu, Jing; Luo, Xiaoyan; Xie, Yimin; Wang, Hua"
作者地址："[Chen, Qiang; Zhang, Yunxuan; Ni, Sili; Li, Jiwei; Yuan, Xingang; Luo, Xiaoyan; Wang, Hua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders,Childrens Hosp,Dept, Chongqing Key Lab Child Rare Dis Infect & Immun,Mi, Chongqing, Peoples R China; [Chen, Qiang; Chen, Meng; Liu, Jing; Xie, Yimin] Chongqing Univ, Dept Pediat Surg, Three Gorges Hosp, Chongqing, Peoples R China; [Yang, Liuqing] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Chongqing, Key Lab Child Dev & Disorders,China Int Sci & Tech, Dept Neonatol,Childrens Hosp,Minist Educ,Pediat Re, Chongqing, Peoples R China; [Wang, Hua] Chongqing Med Univ, Dept Dermatol, Childrens Hosp, Chongqing 400014, Peoples R China; [Xie, Yimin] Chongqing Univ, Dept Pediat Surg, Three Gorges Hosp, Chongqing 404000, Peoples R China"
通信作者："Wang, H (通讯作者)，Chongqing Med Univ, Dept Dermatol, Childrens Hosp, Chongqing 400014, Peoples R China.; Xie, YM (通讯作者)，Chongqing Univ, Dept Pediat Surg, Three Gorges Hosp, Chongqing 404000, Peoples R China."
来源：PEDIATRIC BLOOD & CANCER
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:001199750000001
JCR分区：Q1
影响因子：2.4
年份：2024
卷号：
期号：
开始页：
结束页：
文献类型：Article; Early Access
关键词：apelin; biomarker; infantile hemangioma; VEGF
摘要："BackgroundInfantile hemangiomas (IHs) are common benign vascular tumors in infants. Apelin, an endogenous cytokine, is implicated in the angiogenesis of neoplastic diseases. We aimed to explore the association between apelin and IHs, providing a foundation for clinical applications.MethodsWe identified differential expression of apelin in proliferative IHs compared to healthy controls (HCs) through bioinformatics analysis of publicly available databases and verified by Immunofluorescence. Enzyme-linked immunosorbent assay was used to quantify the serum levels of apelin and vascular endothelial growth factor (VEGF) in a cohort of 116 cases of proliferative IHs, 65 cases of capillary malformations (CMs), and 70 HCs.ResultsApelin and APJ (APLNR, apelin receptor) were identified as the significantly upregulated differentially expressed genes (DEGs) in proliferative IHs. Immunofluorescence staining indicated high expression of apelin in proliferative IHs, while minimal expression in non-IH lesions. Apelin in IHs was reduced following 6 months of propranolol treatment. Serum apelin levels were significantly higher in the IH group compared to both the CM and HC groups. Moreover, apelin exhibited excellent discriminatory ability in distinguishing IHs from HCs, with an area under the curve (AUC) exceeding 0.90. A positive correlation was observed between the levels of apelin and the size of superficial IHs. The expression profiles of VEGF and apelin in IHs were found to be consistent.ConclusionsApelin shows promise as a potential biomarker for IHs. The association between apelin and IH size, as well as its responsiveness to propranolol treatment, indicates its possible utility as a valuable indicator for the therapeutic evaluation of IHs."
基金机构：Chongqing Postgraduate Scientific Research Innovation Project; Children's Hospital of Chongqing Medical University; National Children's Health and Disease Clinical Medical Research Center Youth Program of Clinical Medical Research; [CYB22209]
基金资助正文："We sincerely thank the patients and family members for participating in this study. We extend our gratitude to the Children's Hospital of Chongqing Medical University and Chongqing University Three Gorges Hospital for their invaluable support in facilitating this study. Additionally, we would like to express our appreciation for the funding received from the Chongqing Postgraduate Scientific Research Innovation Project (CYB22209 to Qiang Chen) and the National Children's Health and Disease Clinical Medical Research Center Youth Program of Clinical Medical Research (NCRCCHD-2022-YP-OX to Sili Ni)."
