Analysis of risk factors related to the progression rate of hemifacial spasm

作者全名："Xu, Fei; Gu, Pengju; Yuan, Huan; Jiang, Li; Xie, Yanfeng; Shi, Quanhong; Zhan, Yan"

作者地址："[Xu, Fei; Gu, Pengju; Yuan, Huan; Jiang, Li; Xie, Yanfeng; Shi, Quanhong; Zhan, Yan] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："Zhan, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001199917000001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：hemifacial spasm; progression rate; facial nerve angel; root entry zone; APOE epsilon 4; magnetic resonance tomography angiography

摘要："Introduction: Although there have been many researches on the etiology and risk factors with the onset of hemifacial spasm, researches on the risk factors related to progression rate are limited. This study aims to analyze the risk factors related to the progression rate of hemifacial spasm. Methods: The study enrolled 142 patients who underwent microvascular decompression for hemifacial spasm. Based on the duration and severity of symptoms, patients were classified into rapid progression group and slow progression group. To analyze risk factors, univariate and multivariate logistic regression analyses were conducted. Of 142 patients with hemifacial spasm, 90(63.3%) were classified as rapid progression group, 52(36.7%) were classified as slow progression group. Results: In the univariate analysis, there were significant statistical differences between the two groups in terms of age of onset (P = 0.021), facial nerve angle (P < 0.01), hypertension (P = 0.01), presence of APOE epsilon 4 expression (P < 0.01) and different degrees of brainstem compression in the Root Entry Zone (P < 0.01). In the multivariable analyses, there were significant statistical differences between the two groups in terms of age of symptom onset (P < 0.01 OR = 6.591), APOE epsilon 4 (P < 0.01 OR = 5.691), brainstem compression (P = 0.006 OR = 5.620), and facial nerve angle (P < 0.01 OR = 5.758). Furthermore, we found no significant correlation between the severity of facial spasms and the progression rate of the disease (t = 2.47, P = 0.12>0.05). Conclusion: According to our study, patients with facial nerve angle <= 96.5 degrees, severer compression of the brainstem by offending vessels, an onset age > 45 years and positive expression of APOE epsilon 4, may experience faster progression of hemifacial spasm."

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