"Metabolic dysfunction, rather than obesity, is a risk factor for chronic kidney disease in Chinese population"

作者全名："Yang, Shan; Ling, Jiaxiu; Zhang, Siliang; Li, Yang; Yang, Gangyi"

作者地址："[Yang, Shan; Ling, Jiaxiu; Zhang, Siliang; Li, Yang; Yang, Gangyi] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Yang, GY (通讯作者)，Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：AGING MALE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001201350900001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：27

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Obesity; metabolic dysfunction; body mass index; chronic kidney disease; CHARLS

摘要："Background: Metabolic dysfunction and obesity are closely related to chronic kidney disease (CKD). However, studies on the relationship between various metabolic syndrome-body mass index (MetS-BMI) phenotypes and the risk of CKD in the Chinese population have not yet been explored. Materials and methods: Data from the China Health and Retirement Longitudinal Study (CHARLS) 2015 were analyzed in this study. This study enrolled 12,054 participants. Participants were divided into six distinct groups according to their MetS-BMI status. Across the different MetS-BMI groups, the odd ratios (ORs) for CKD were determined using multivariable logistic regression models. Results: The prevalence of CKD was higher in metabolically unhealthy groups than in the corresponding healthy groups. Moreover, the fully adjusted model showed that all metabolically unhealthy individuals had an increased risk of developing CKD compared to the metabolically healthy normal weight group (OR = 1.62, p = 0.002 for the metabolically unhealthy normal weight group; OR = 1.55, p < 0.001 for the metabolically unhealthy overweight group; and OR = 1.77, p < 0.001 for the metabolically unhealthy obesity group. Conclusions: This study is the first to evaluate the relationship between the MetS-BMI phenotype and renal prognosis in the Chinese population. Individuals with normal weights are at different risk of developing CKD depending on their different metabolic phenotypes."

基金机构：National Natural Science Foundation of China [82100824]; Chinese Postdoctoral Science Foundation [2021M700633]

基金资助正文：This study was supported by the National Natural Science Foundation of China (Grant No. 82100824) and the Chinese Postdoctoral Science Foundation (Grant No. 2021M700633).