Comparative study of imaging and pathology of primary mucinous adenocarcinoma with different imaging manifestations

作者全名："Han, Jun; Gao, Jie; Chen, Demei; Du, Mou; Wu, Yuxin; Ma, Xidong; Xie, Mei; Han, Hua; Wu, Chongchong; Xue, Xinying"

作者地址："[Han, Jun] Chongqing Med Univ, Affiliated Hosp 3, Dept Radiol, Chongqing, Peoples R China; [Gao, Jie] Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing, Peoples R China; [Chen, Demei] Chongqing Univ, Canc Hosp, Dept Nucl Med, Chongqing, Peoples R China; [Du, Mou] Sichuan Univ, Dept Radiol, West China Sch Publ Hlth, Chengdu, Sichuan, Peoples R China; [Du, Mou] Sichuan Univ, West China Hosp 4, Chengdu, Sichuan, Peoples R China; [Wu, Yuxin] Tradit Chinese Med Hosp Changshou Dist, Dept Radiol, Chongqing, Peoples R China; [Ma, Xidong; Xie, Mei] Chinese Peoples Liberat Army Gen Hosp, Dept Resp & Crit Care, Beijing, Peoples R China; [Han, Hua] Jinzhou Med Univ, Dept Radiol, Affiliated Hosp 3, Jinzhou, Liaoning, Peoples R China; [Wu, Chongchong] Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China; [Xue, Xinying] Capital Med Univ, Beijing Shijitan Hosp, Dept Resp & Crit Care, Beijing, Peoples R China; [Xue, Xinying] Capital Med Univ, Beijing Shijitan Hosp, Dept Resp Dis, Beijing, Peoples R China"

通信作者："Han, H (通讯作者)，Jinzhou Med Univ, Dept Radiol, Affiliated Hosp 3, Jinzhou, Liaoning, Peoples R China.; Wu, CC (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China.; Xue, XY (通讯作者)，Capital Med Univ, Beijing Shijitan Hosp, Dept Resp Dis, Beijing, Peoples R China."

来源：CLINICAL RESPIRATORY JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001201705500001

JCR分区：Q3

影响因子：1.9

年份：2024

卷号：18

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：adenocarcinoma; gene; imaging; mucus; pathological manifestation

摘要："BackgroundPulmonary mucinous adenocarcinoma is a special type of lung cancer. Its imaging manifestations are diverse, which brings challenges to clinical diagnosis. However, its formation mechanism is unclear.ObjectiveThe objective of this study is to analyse the relevant mechanisms of the formation of pulmonary mucinous adenocarcinoma by observing its different imaging and pathological manifestations.Data and methodsRetrospective analysis was conducted on imaging manifestations and pathological data of 103 patients with pulmonary mucinous adenocarcinoma confirmed intraoperatively or pathologically.ResultsForty-three patients had pulmonary mucinous adenocarcinoma with a solitary nodule/mass, 41 patients with localized pneumonia and 19 patients with diffuse pneumonia. Their CT manifestations included 'falling snowflake sign', ground-glass opacity close to the heart, vacuous signs/honeycombing and withered tree branches. Under the microscope, all the three types of pulmonary mucinous adenocarcinoma had visibly formed mucus lakes but were made of tumour cells with totally different shapes, which included the goblet-like shape (tall column-like shape) and quasi-circular shape. Tall column-shaped tumour cells were negative or weakly positive for thyroid transcription factor-1 (TTF-1) and strongly positive for ALK mutation, whereas quasi-circular tumour cells were positive for TTF-1 and less positive for ALK mutation.ConclusionThe different imaging manifestations of mucinous adenocarcinoma are possibly due to the different amounts or viscosity of mucus produced, and the mechanisms of its formation may include (1) tumour cells in different shapes have different abilities to produce mucus; (2) tumours in different stages produce different amounts or viscosity of mucus; and (3) the TTF-1 and ALK genes affect the production of mucus. In this work, retrospective analysis was conducted on imaging manifestations and pathological data of 103 patients with pulmonary mucinous adenocarcinoma confirmed intraoperatively or pathologically. The different imaging manifestations of mucinous adenocarcinoma are possibly due to the different amounts or viscosity of mucus produced. image"

基金机构：National Natural Science Foundation of China; Talent Training Program of Beijing Shijitan Hospital Affiliated to Capital Medical University [2023DTRXXY]; [62176166]

基金资助正文：This study was funded by the National Natural Science Foundation of China (No. 62176166) and the Talent Training Program of Beijing Shijitan Hospital Affiliated to Capital Medical University during the 14th Five Year Plan period (No. 2023DTRXXY).