Comparison of <i>Mycoplasma pneumoniae</i> infection in children admitted with community acquired pneumonia before and during the COVID-19 pandemic: a retrospective study at a tertiary hospital of southwest China

作者全名：Ai, Ling; Liu, Beizhong; Fang, Liang; Zhou, Chanjuan; Gong, Fang

作者地址：[Ai, Ling; Gong, Fang] Chongqing Med Univ, Yongchuan Hosp, Dept Gen Practice, 439, Xuanhua St, Chongqing 402160, Peoples R China; [Ai, Ling] Southwest Med Univ, Affiliated Hosp, Dept Resp & Crit Care Med, Luzhou 646000, Sichuan, Peoples R China; [Ai, Ling; Liu, Beizhong; Fang, Liang; Zhou, Chanjuan; Gong, Fang] Chongqing Med Univ, Yongchuan Hosp, Cent Lab, Chongqing 402160, Peoples R China; [Liu, Beizhong] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing 402160, Peoples R China; [Fang, Liang; Zhou, Chanjuan] Chongqing Med Univ, Dept Lab Med, Minist Educ, Key Lab Lab Med Diagnost, Chongqing 400016, Peoples R China; [Gong, Fang] Chongqing Med Univ, Yongchuan Hosp, Dept Pediat, Chongqing 402160, Peoples R China

通信作者：Gong, F (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Dept Gen Practice, 439, Xuanhua St, Chongqing 402160, Peoples R China.; Gong, F (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Cent Lab, Chongqing 402160, Peoples R China.; Gong, F (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Dept Pediat, Chongqing 402160, Peoples R China.

来源：EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001202037700001

JCR分区：Q2

影响因子：3.7

年份：2024

卷号：43

期号：6

开始页：1213

结束页：1220

文献类型：Article

关键词：COVID-19; Mycoplasma pneumoniae; Epidemiology; Community acquired pneumonia; Pediatrics

摘要：Purpose The COVID-19 pandemic has notably altered the infection dynamics of various pathogens. This study aimed to evaluate the pandemic's impact on the infection spectrum of Mycoplasma pneumoniae (M. pneumoniae) among children with community acquired pneumonia (CAP). Methods We enrolled pediatric CAP patients admitted to a tertiary hospital in southwest China to compare the prevalence and characteristics of M. pneumoniae infections before (2018-2019) and during (2020-2022) the COVID-19 pandemic. Detection of M. pneumoniae IgM antibodies in serum were conducted using either indirect immunofluorescence or passive agglutination methods. Results The study included 1505 M. pneumoniae-positive and 3160 M. pneumoniae-negative CAP patients. Notable findings were the higher age and frequency of pneumonia-associated symptoms in M. pneumoniae-positive patients, alongside a lower male proportion and fewer respiratory co-infections. The year 2019 saw a notable increase in M. pneumoniae infections compared to 2018, followed by a decline from 2020 to 2022. The COVID-19 pandemic period witnessed significant alterations in age distribution, male proportion, and co-infections with specific pathogens in both M. pneumoniae-positive and negative patients. The M. pneumoniae infections were predominantly seasonal, peaking in autumn and winter during 2018 and 2019. Although there was a sharp drop in February 2020, the infection still peaked in cold months of 2020 and 2021. However, the typical seasonal pattern was nearly absent in 2022. Conclusions The COVID-19 pandemic has markedly changed the infection landscape of M. pneumoniae in pediatric CAP patients, with shifts observed in infection rates, demographic profiles, co-infections, and seasonal patterns.

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