Clinical characteristics and influence of postoperative Hirschsprung-associated enterocolitis: retrospective study at a tertiary children's hospital

作者全名：Feng, Wei; Zhang, Bobin; Fan, Linxiao; Song, Aohua; Hou, Jinping; Die, Xiaohong; Liu, Wei; Wang, Yi; Guo, Zhenhua

作者地址：[Feng, Wei; Zhang, Bobin; Fan, Linxiao; Song, Aohua; Hou, Jinping; Die, Xiaohong; Liu, Wei; Wang, Yi; Guo, Zhenhua] Chongqing Med Univ, Childrens Hosp, Dept Gen & Neonatal Surg, Chongqing, Peoples R China; [Feng, Wei; Zhang, Bobin; Fan, Linxiao; Song, Aohua; Hou, Jinping; Die, Xiaohong; Liu, Wei; Wang, Yi; Guo, Zhenhua] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Feng, Wei; Zhang, Bobin; Fan, Linxiao; Song, Aohua; Hou, Jinping; Die, Xiaohong; Liu, Wei; Wang, Yi; Guo, Zhenhua] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Feng, Wei; Zhang, Bobin; Fan, Linxiao; Song, Aohua; Hou, Jinping; Die, Xiaohong; Liu, Wei; Wang, Yi; Guo, Zhenhua] Chongqing Key Lab Struct Birth Defect & Reconstruc, Chongqing, Peoples R China

通信作者：Guo, ZH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Gen & Neonatal Surg, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Guo, ZH (通讯作者)，Chongqing Key Lab Struct Birth Defect & Reconstruc, Chongqing, Peoples R China.

来源：PEDIATRIC SURGERY INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001202045600002

JCR分区：Q2

影响因子：1.5

年份：2024

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Hirschsprung-associated enterocolitis; Hirschsprung's disease; Clinical characteristic; Influence

摘要：Purpose To explore the influence of postoperative Hirschsprung-associated enterocolitis (post-HAEC) on long-term outcomes and to identify risk factors of post-HAEC. Methods The medical records of 304 eligible patients diagnosed with Hirschsprung's disease (HSCR) were reviewed. We analyzed the clinical characteristics of post-HAEC and its influence on long-term outcomes. Furthermore, risk factors for early and recurrent HAEC were identified separately. Results The overall incidence of post-HAEC was 29.9% (91/304). We categorized early HAEC as occurring within postoperative 3 months (n = 39) and recurrent HAEC as occurring >= 3 episodes within postoperative 6 months (n = 25). Patients with early HAEC were more likely to experience worse nutritional status, defecation function, and quality of life compared to those with late or no episodes (P < 0.05). Similarly, the adverse influences of recurrent HAEC on these outcomes were also significant (P < 0.05). The risk factors for early HAEC included preoperative undernutrition, long-segment HSCR, and postoperative Grade 3-4 complications within 30 days. For recurrent HAEC, risk factors were preoperative malnutrition, non-parental caregivers, long-segment HSCR, and postoperative Grade 3-4 complications within 30 days. Conclusion Classification of post-HAEC based on the first episode time and frequency was necessary. The earlier or more frequent episodes of post-HAEC have detrimental influences on long-term outcomes. Furthermore, risk factors for early and recurrent HAEC were different.

基金机构：Research grants from the National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University

基金资助正文：No Statement Available