pH-Responsive manganese sulfide nanotheranostics amplifying cGAS-STING activation for MRI-guided immunotherapy

作者全名："Zhang, Tingting; Tan, Mingya; Fan, Mengke; Zhao, Zhenghuan; Peng, Zhiping"

作者地址："[Zhang, Tingting; Tan, Mingya; Fan, Mengke; Zhao, Zhenghuan; Peng, Zhiping] Chongqing Med Univ, Coll Basic Med, Chongqing 400016, Peoples R China"

通信作者："Peng, ZP (通讯作者)，Chongqing Med Univ, Coll Basic Med, Chongqing 400016, Peoples R China."

来源：NEW JOURNAL OF CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:001203664000001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：　

期号：　

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结束页：　

文献类型：Article; Early Access

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摘要："Manganese-based nanomaterials have attracted great interest in cancer nanotheranostics owing to their excellent physicochemical properties. Herein, we report alpha-phase manganese sulfide nanotheranostics (MnSN) as an MRI-guided chemodynamic therapy agent and cGAS-STING agonist for tumor immunotherapy. MnSN can degrade into manganese ions in response to the mildly acidic tumor microenvironment. This unique feature endows MnSN with the ability to produce sufficient hydroxyl radicals (OH) and achieve efficient chemodynamic therapy in vitro and vivo. More importantly, the released manganese ions successfully activate the cGAS-STING pathway, resulting in the significant immune effect and inhibiting the tumor metastasis. Besides, the pH-responsive degradation endows MnSN with activable T1 magnetic resonance imaging to monitor the treatment progress. This study demonstrates that MnSN holds great potential for the precise diagnosis and inhibition of tumor growth and metastasis. A multifunctional manganese sulfide nanotheranostics has been prepared for magnetic resonance imaging, chemodynamic therapy and immunotherapy based on the cGAS-STING pathway."

基金机构：Creative Research Group of CQ University [CXQT21017]

基金资助正文：This work was supported by the Creative Research Group of CQ University (CXQT21017).