Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics

作者全名：Luo, Ya-Xi; Yang, Ling-Ling; Yao, Xiu-Qing

作者地址：[Luo, Ya-Xi; Yang, Ling-Ling; Yao, Xiu-Qing] Chongqing Med Univ, Dept Rehabil, Affiliated Hosp 2, Chongqing, Peoples R China; [Yao, Xiu-Qing] Chongqing Municipal Clin Res Ctr Geriatr Med, Chongqing, Peoples R China; [Yao, Xiu-Qing] Chongqing Med Univ, Dept Rehabil Therapy, Chongqing, Peoples R China

通信作者：Yao, XQ (通讯作者)，Chongqing Med Univ, Dept Rehabil, Affiliated Hosp 2, Chongqing, Peoples R China.; Yao, XQ (通讯作者)，Chongqing Municipal Clin Res Ctr Geriatr Med, Chongqing, Peoples R China.; Yao, XQ (通讯作者)，Chongqing Med Univ, Dept Rehabil Therapy, Chongqing, Peoples R China.

来源：MOLECULAR NEURODEGENERATION

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001204486000001

JCR分区：Q1

影响因子：14.9

年份：2024

卷号：19

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Gut microbiota; Lipid metabolism; Alzheimer's disease; Cholesterol; SCFAs; LPS; APOE; Neuroinflammation; Probiotics; Lifestyle; Exercise

摘要：Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer's disease. The role of gut microbiota in Alzheimer's disease is diverse and complex, evidence suggests lipid metabolism may be one of the potential pathways. However, the mechanisms that gut microbiota mediate lipid metabolism in Alzheimer's disease pathology remain unclear, necessitating further investigation for clarification. This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer's disease based on existing data.

基金机构：National Natural Science Foundation of China

基金资助正文：All diagrams are created with BioRender.com.