Total sleep deprivation alters spontaneous brain activity in medical staff during routine clinical work: a resting-state functional MR imaging study

作者全名：Peng, Cong; Guo, Dingbo; Liu, Liuheng; Xiao, Dongling; Nie, Lisha; Liang, Huilou; Guo, Dajing; Yang, Hua

作者地址：[Peng, Cong; Guo, Dingbo; Liu, Liuheng; Yang, Hua] Chongqing Hosp Tradit Chinese Med, Dept Radiol, Chongqing, Peoples R China; [Peng, Cong; Guo, Dajing] Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing, Peoples R China; [Peng, Cong] Chongqing Gen Hosp, Dept Radiol, Chongqing, Peoples R China; [Xiao, Dongling] Third Mil Med Univ, Army Med Univ, Dept Anat, Key Lab Biomech & Tissue Engn Chongqing, Chongqing, Peoples R China; [Nie, Lisha; Liang, Huilou] GE Healthcare, MR Res, Beijing, Peoples R China

通信作者：Yang, H (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Radiol, Chongqing, Peoples R China.; Guo, DJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing, Peoples R China.

来源：FRONTIERS IN NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001204829700001

JCR分区：Q2

影响因子：3.2

年份：2024

卷号：18

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：total sleep deprivation; resting-state functional MRI; routine clinical; amplitude of low-frequency fluctuation (ALFF); regional homogeneity (ReHo); functional connectivity

摘要：Objectives To assess the effect of total sleep deprivation (TSD) on spontaneous brain activity in medical staff during routine clinical practice.Methods A total of 36 medical staff members underwent resting-state functional MRI (rs-fMRI) scans and neuropsychological tests twice, corresponding to rested wakefulness (RW) after normal sleep and 24 h of acute TSD. The rs-fMRI features, including the mean fractional amplitude of low-frequency fluctuation (mfALFF), z-score transformed regional homogeneity (zReHo), and functional connectivity (zFC), were compared between RW and TSD. Correlation coefficients between the change in altered rs-fMRI features and the change in altered scores of neuropsychological tests after TSD were calculated. Receiver operating characteristic (ROC) and logistic regression analyses were performed to evaluate the diagnostic efficacy of significantly altered rs-fMRI features in distinguishing between RW and TSD states.Results Brain regions, including right superior temporal gyrus, bilateral postcentral gyrus, left medial superior frontal gyrus, left middle temporal gyrus, right precentral gyrus, and left precuneus, showed significantly enhanced rs-fMRI features (mfALFF, zReHo, zFC) after TSD. Moreover, the changes in altered rs-fMRI features of the right superior temporal gyrus, bilateral postcentral gyrus, left middle temporal gyrus, and left precuneus were significantly correlated with the changes in several altered scores of neuropsychological tests. The combination of mfALFF (bilateral postcentral gyrus) and zFC (left medial superior frontal gyrus and left precuneus) showed the highest area under the curve (0.870) in distinguishing RW from TSD.Conclusion Spontaneous brain activity alterations occurred after TSD in routine clinical practice, which might explain the reduced performances of these participants in neurocognitive tests after TSD. These alterations might be potential imaging biomarkers for assessing the impact of TSD and distinguishing between RW and TSD states.

基金机构：Natural Science Foundation of Chongqing Municipal Government [CSTB2023NSCQ-BHX0054]; Chengdu University of Traditional Chinese Medicine "Xinglin Scholars" Discipline Talent Research Enhancement Plan Hospital Special Project [YYZX2021078]

基金资助正文：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by Natural Science Foundation of Chongqing Municipal Government (CSTB2023NSCQ-BHX0054), Chengdu University of Traditional Chinese Medicine "Xinglin Scholars" Discipline Talent Research Enhancement Plan Hospital Special Project (YYZX2021078).