Comparison of early patient-reported outcomes between uniportal thoracoscopic segmentectomy and wedge resection for peripheral small-sized non-small-cell lung cancer

作者全名：Zhao, Yingzhi; Liu, Wenwu; Gao, Xin; Zhang, Kaixin; Dai, Wei; Wei, Xing; Zheng, Haoqian; Lei, Cheng; Yu, Hongfan; Shi, Qiuling; Li, Qiang; Xie, Tianpeng

作者地址：[Zhao, Yingzhi; Liu, Wenwu; Gao, Xin; Dai, Wei; Wei, Xing; Zheng, Haoqian; Shi, Qiuling; Li, Qiang; Xie, Tianpeng] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc, Sichuan Canc Ctr,Affiliated Canc Hosp,Dept Thorac, Chengdu 610041, Sichuan, Peoples R China; [Zhang, Kaixin] Sichuan Canc Hosp, Sichuan Clin Res Ctr Canc, Dept Thorac Surg, Chengdu 610041, Sichuan, Peoples R China; [Zhang, Kaixin] Chengdu Med Coll, Grad Sch, Chengdu 610041, Sichuan, Peoples R China; [Lei, Cheng; Shi, Qiuling] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Yu, Hongfan; Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China

通信作者：Xie, TP (通讯作者)，Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc, Sichuan Canc Ctr,Affiliated Canc Hosp,Dept Thorac, Chengdu 610041, Sichuan, Peoples R China.

来源：JOURNAL OF CARDIOTHORACIC SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001205004600001

JCR分区：Q3

影响因子：1.5

年份：2024

卷号：19

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Non-small cell lung carcinoma; Patient-reported outcomes; Pneumonectomy

摘要：Background Analysis of patient-reported outcomes (PROs) offers valuable insights into distinguishing the effects of closely related medical procedures from the patient's perspective. In this study we compared symptom burden in patients undergoing uniportal thoracoscopic segmentectomy and wedge resection for peripheral small-sized non-small cell lung cancer (NSCLC). Methods This study included patients with peripheral NSCLC from an ongoing longitudinal prospective cohort study (CN-PRO-Lung 3) who underwent segmentectomy or wedge resection with tumor diameter <= 2 cm and consolidation tumor ratio (CTR) <= 0.5. PROs data were collected using the Perioperative Symptom Assessment for Lung Surgery questionnaire pre-operatively, daily post-surgery up to the fourth hospitalization day, and weekly post-discharge up to the fourth week. Propensity score matching and a generalized estimation equation model were employed to compare symptom severity. In addition, short-term clinical outcomes were compared. Results In total, data of 286 patients (82.4%) undergoing segmentectomy and 61 patients (17.6%) undergoing wedge resection were extracted from the cohort. No statistically significant differences were found in the proportion of moderate-to-severe symptoms and mean scores for pain, cough, shortness of breath, disturbed sleep, fatigue, drowsiness, and distress during the 4-day postoperative hospitalization or the 4-week post-discharge period before or after matching (all p > 0.05). Compared with segmentectomy, wedge resection showed better short-term clinical outcomes, including shorter operative time (p = 0.001), less intraoperative bleeding (p = 0.046), and lower total hospital costs (p = 0.002). Conclusions The study findings indicate that uniportal thoracoscopic segmentectomy and wedge resection exert similar early postoperative symptom burden in patients with peripheral NSCLC (tumor diameter <= 2 cm and CTR <= 0.5).

基金机构：Sichuan Science and Technology Program

基金资助正文：The authors thank Editage (www.editage.com) for English language editing. The authors thank Xin Nie for his statistical consultation.